Featured Research

from universities, journals, and other organizations

Infection is an important post-stroke problem

Date:
December 8, 2011
Source:
University of Calgary
Summary:
After a stroke the brain tries to protect itself by blocking all inflammation. However, this also makes the patient highly susceptible to infection which can lead to death. Researchers have now discovered the mechanism behind this response and how to possibly treat it.

After a stroke the brain tries to protect itself by blocking all inflammation. However, this also makes the patient highly susceptible to infection which can lead to death. Researchers have now discovered the mechanism behind this response and how to possibly treat it.

The research is published this month in the journal Science.

Using a mouse model, scientists at the University of Calgary's Faculty of Medicine have discovered Natural Killer T-cells (NKT) are the immune cells that get activated in the patient after a stroke. The cells suppress the immune system as the body tries to prevent inflammation to protect the brain. The researchers have also found a new drug that can stop the NKT cells from suppressing the immune system, stopping the infections.

"When we discovered that these novel NKT cells are important in fighting infection in stroke, we were able to specifically target them. This means that infections can be controlled without having to administer high levels of antibiotics," says Paul Kubes, PhD, senior author of the study and director of the Snyder Institute at the University of Calgary. "This in its own right is important to avoid over-usage of antibiotics leading to development of anti-biotic resistant strains of bacteria."

Early indications are that NKT cells in humans behave very similarly to NKT cells in mice making this highly relevant to human stroke.

"The research does not cure the stroke itself," says Connie Wong, PhD , also a co-author of the study and member of the Snyder Institute at the University of Calgary , "But by providing novel therapies it holds the promise to significantly decrease death rates associated with stroke."

This research publication has recently been recognized by Faculty of 1000, a website for researchers that identifies and evaluates the most significant articles from biomedical research publications.

The research was supported by the Canadian Institutes for Health Research (CIHR). Paul Kubes' research is also funded by Alberta Innovates -- Health Solutions.


Story Source:

The above story is based on materials provided by University of Calgary. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. H. Y. Wong, C. N. Jenne, W.-Y. Lee, C. Leger, P. Kubes. Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke. Science, 2011; 334 (6052): 101 DOI: 10.1126/science.1210301

Cite This Page:

University of Calgary. "Infection is an important post-stroke problem." ScienceDaily. ScienceDaily, 8 December 2011. <www.sciencedaily.com/releases/2011/10/111026122440.htm>.
University of Calgary. (2011, December 8). Infection is an important post-stroke problem. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2011/10/111026122440.htm
University of Calgary. "Infection is an important post-stroke problem." ScienceDaily. www.sciencedaily.com/releases/2011/10/111026122440.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins