Featured Research

from universities, journals, and other organizations

Infection is an important post-stroke problem

Date:
December 8, 2011
Source:
University of Calgary
Summary:
After a stroke the brain tries to protect itself by blocking all inflammation. However, this also makes the patient highly susceptible to infection which can lead to death. Researchers have now discovered the mechanism behind this response and how to possibly treat it.

After a stroke the brain tries to protect itself by blocking all inflammation. However, this also makes the patient highly susceptible to infection which can lead to death. Researchers have now discovered the mechanism behind this response and how to possibly treat it.

The research is published this month in the journal Science.

Using a mouse model, scientists at the University of Calgary's Faculty of Medicine have discovered Natural Killer T-cells (NKT) are the immune cells that get activated in the patient after a stroke. The cells suppress the immune system as the body tries to prevent inflammation to protect the brain. The researchers have also found a new drug that can stop the NKT cells from suppressing the immune system, stopping the infections.

"When we discovered that these novel NKT cells are important in fighting infection in stroke, we were able to specifically target them. This means that infections can be controlled without having to administer high levels of antibiotics," says Paul Kubes, PhD, senior author of the study and director of the Snyder Institute at the University of Calgary. "This in its own right is important to avoid over-usage of antibiotics leading to development of anti-biotic resistant strains of bacteria."

Early indications are that NKT cells in humans behave very similarly to NKT cells in mice making this highly relevant to human stroke.

"The research does not cure the stroke itself," says Connie Wong, PhD , also a co-author of the study and member of the Snyder Institute at the University of Calgary , "But by providing novel therapies it holds the promise to significantly decrease death rates associated with stroke."

This research publication has recently been recognized by Faculty of 1000, a website for researchers that identifies and evaluates the most significant articles from biomedical research publications.

The research was supported by the Canadian Institutes for Health Research (CIHR). Paul Kubes' research is also funded by Alberta Innovates -- Health Solutions.


Story Source:

The above story is based on materials provided by University of Calgary. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. H. Y. Wong, C. N. Jenne, W.-Y. Lee, C. Leger, P. Kubes. Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke. Science, 2011; 334 (6052): 101 DOI: 10.1126/science.1210301

Cite This Page:

University of Calgary. "Infection is an important post-stroke problem." ScienceDaily. ScienceDaily, 8 December 2011. <www.sciencedaily.com/releases/2011/10/111026122440.htm>.
University of Calgary. (2011, December 8). Infection is an important post-stroke problem. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/10/111026122440.htm
University of Calgary. "Infection is an important post-stroke problem." ScienceDaily. www.sciencedaily.com/releases/2011/10/111026122440.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins