Featured Research

from universities, journals, and other organizations

One molecule for muscle growth and insulin sensitivity

Date:
January 21, 2012
Source:
Cell Press
Summary:
Two independent studies suggest a common way to pump up muscles and prevent diabetes. The key is a molecule required for fine-tuning metabolism by selectively and subtly modifying core metabolic programs.

Two independent studies in the Nov. 11 issue of the journal Cell, a Cell Press publication, suggest a common way to pump up muscles and prevent diabetes. The key is a molecule required for fine-tuning metabolism by selectively and subtly modifying core metabolic programs.

Researchers show that loss of this molecule specifically in muscle produces mice with more fat-burning muscle and greater exercise capacity. "We turned mice into super-marathon mice," said Johan Auwerx of École Polytechnique Fédérale de Lausanne. "They had more stamina and more endurance."

Another group of researchers show that loss of the same molecule specifically in fat cells produces mice that become more insulin sensitive even as they grow fatter. Despite being fat, the mice are a lot like animals on diabetes drugs known collectively as TZDs (thiazolidinediones) minus the side effects of water rention and heart diesease. "They were more glucose tolerant, even though they were more obese," said Jerrold Olefsky of the University of California, San Diego. "They were less insulin resistant and had less systemic inflammation -- all features common to TZD treatment."

This molecule is is called NCoR. It integrates complex signaling pathways, adjusting specific metabolic programs in a manner similar to a dimmer switch, Auwerx explains. The particular genes it acts on apparently vary with cell type.

These studies are surprising because earlier work had shown that complete loss of NCoR early in development is fatal. Scientists, including Auwerx and Olefsky, had anticipated that NCoR in specific adult cells would have broader effects than it does.

What these findings suggest is that limiting the levels or activity of NCoR could improve human metabolism for the better. It might be possible to produce drugs that specifically target NCoR activity only in one tissue or another. Olefsky's work suggests that fat is the prime target for improving insulin sensitivity since the mice with changes only in adipose experience systemic improvements.

"There is no doubt where this begins," Olefsky says, "and with this adipocyte [NCoR] knockout you get systemic insulin sensitivity; the liver and muscle gets better too."

The fact that NCoR deficiency comes with benefits in two totally different contexts makes such a treatment strategy that much more compelling, Auwerx said. "At the end of the day, it's doing something good for metabolism," Olefsky said.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pingping Li, WuQiang Fan, Jianfeng Xu, Min Lu, Hiroyasu Yamamoto, Johan Auwerx, Dorothy D. Sears, Saswata Talukdar, DaYoung Oh, Ai Chen, Gautam Bandyopadhyay, Miriam Scadeng, Jachelle M. Ofrecio, Sarah Nalbandian, Jerrold M. Olefsky. Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity. Cell, 2011; 147 (4): 815 DOI: 10.1016/j.cell.2011.09.050

Cite This Page:

Cell Press. "One molecule for muscle growth and insulin sensitivity." ScienceDaily. ScienceDaily, 21 January 2012. <www.sciencedaily.com/releases/2011/11/111110125723.htm>.
Cell Press. (2012, January 21). One molecule for muscle growth and insulin sensitivity. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2011/11/111110125723.htm
Cell Press. "One molecule for muscle growth and insulin sensitivity." ScienceDaily. www.sciencedaily.com/releases/2011/11/111110125723.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) — New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins