Featured Research

from universities, journals, and other organizations

Head and neck cancer: Study identifies factors associated with increased risk of death among two-year survivors

Date:
November 28, 2011
Source:
JAMA and Archives Journals
Summary:
Among patients with head and neck cancer, poor overall quality of life, pain, and continued tobacco use appear to be associated with poorer outcomes and higher mortality rate two years after diagnosis, according to a new study.

Among patients with head and neck cancer, poor overall quality of life, pain, and continued tobacco use appear to be associated with poorer outcomes and higher mortality rate two years after diagnosis, according to a report in the November issue of the Archives of Otolaryngology -- Head & Neck Surgery, one of the JAMA/Archives journals.

Related Articles


"A conditional survival rate is the probability of surviving after having already lived for a certain length of time," the authors write as background information in the study. "This concept is important in the care of patients with head and neck cancer because it underlies the intuition of head and neck oncologists that mortality and recurrence rates are lower for patients further out from diagnoses."

Trisha L. Thompson, B.S., and colleagues from the University of Iowa Hospital and Clinics, Iowa City, conducted an observational study of 276 patients who survived two years after a diagnosis of upper aerodigestive carcinoma, and were diagnosed between September 2001 and September 2008. Data were collected using standard surveys and short-item queries. Of the 276 participants included in the analysis, 59.9 percent were previous users of tobacco, while 11.4 percent were current users, two years after diagnosis. Additionally, two years after diagnosis, 86 percent of survivors were eating a full diet and 80.5 percent reported having no pain.

The five-year traditional observed survival rate was 61.1 percent for all patients compared with the conditional rate of 90.8 percent for two-year survivors. The five-year traditional disease-specific rate was 69.8 percent for all patients, compared with the conditional rate of 94.8 percent for two-year survivors. Older age and advanced stage were associated with poorer survival, whether death was due to the cancer or from all causes. Patients with pain or poor overall quality of life were more likely to die from all causes, whereas those still smoking two years after diagnoses were more likely to die from their cancer.

The authors found that the likelihood of death was four times lower for patients reporting high overall quality of life than for those reporting low quality of life, and two times higher for those who reported the presence of pain, compared to participants who did not. Additionally, those who continued to use tobacco had a likelihood of death from cancer four times higher than those who had quit or had never used tobacco.

"In addition to older age and advanced stage, which are known to have a negative effect on survival, the presence of pain and continued tobacco use should flag patients who might need longer and more intense follow-up care to improve their observed and disease-specific survival rates," the authors conclude. "This information is useful for clinicians in the development of management plans for patients who are transitioning from treatment into survivorship."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. L. Thompson, N. A. Pagedar, L. H. Karnell, G. F. Funk. Factors Associated With Mortality in 2-Year Survivors of Head and Neck Cancer. Archives of Otolaryngology - Head and Neck Surgery, 2011; 137 (11): 1100 DOI: 10.1001/archoto.2011.179

Cite This Page:

JAMA and Archives Journals. "Head and neck cancer: Study identifies factors associated with increased risk of death among two-year survivors." ScienceDaily. ScienceDaily, 28 November 2011. <www.sciencedaily.com/releases/2011/11/111122115522.htm>.
JAMA and Archives Journals. (2011, November 28). Head and neck cancer: Study identifies factors associated with increased risk of death among two-year survivors. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/11/111122115522.htm
JAMA and Archives Journals. "Head and neck cancer: Study identifies factors associated with increased risk of death among two-year survivors." ScienceDaily. www.sciencedaily.com/releases/2011/11/111122115522.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins