Featured Research

from universities, journals, and other organizations

Newly discovered heart stem cells make muscle and bone

Date:
January 24, 2012
Source:
Cell Press
Summary:
Researchers have identified a new and relatively abundant pool of stem cells in the heart. The findings show that these heart cells have the capacity for long-term expansion and can form a variety of cell types, including muscle, bone, neural and heart cells.

Researchers have identified a new and relatively abundant pool of stem cells in the heart. The findings in the December issue of Cell Stem Cell, a Cell Press publication, show that these heart cells have the capacity for long-term expansion and can form a variety of cell types, including muscle, bone, neural and heart cells.

The researchers say the discovery may lay a foundation for much needed regenerative therapies aimed to enhance tissue repair in the heart. The damaged heart often doesn't repair itself well because of the incredibly hostile environment and wide-scale loss of cells, including stem cells, after a heart attack.

"In the end, we want to know how to preserve the stem cells that are there and to circumvent their loss," says Richard Harvey of the Victor Chang Cardiac Research Institute in Australia.

The newly described cardiac stem cells can be found in both developing and adult hearts, the evidence shows. As in the bone marrow and other organs, the colony-forming cells are found in the vicinity of blood vessels.

Harvey says despite the cells' ability to form those other cell types (a characteristic known as multipotency), he nevertheless suspects they have a bias toward heart tissue for a simple reason: "In an evolutionary sense, they've been dedicated to the heart for a long time." He suspects their flexibility is a byproduct of the need to remain responsive to the environment and to many types of injury.

The findings come at an important time, as stem cells harvested from human hearts during surgery are just beginning to show promise for reversing heart attack damage, Harvey noted. "If we are serious about organ regeneration, we need to understand the biology," he says.

Igor Slukvin of the University of Wisconsin echoes that point in an accompanying commentary. "Understanding the developmental biology of the heart is instrumental in developing novel technologies for heart regeneration and cellular therapies," he writes. "It is critical to identify the type and origin of cells capable of reconstituting a heart."

While cell-based therapies do have potential for repairing damaged heart tissue, Harvey ultimately favors the notion of regenerative therapies designed to tap into the natural ability of the heart and other organs to repair themselves. And there is more work to do to understand exactly what role these stem cells play in that repair process. His team is now exploring some of the factors that bring those cardiac stem cells out of their dormant state in response to injury and protect their "stemness."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. JamesJ.H. Chong, Vashe Chandrakanthan, Munira Xaymardan, NaisanaS. Asli, Joan Li, Ishtiaq Ahmed, Corey Heffernan, MaryK. Menon, ChristopherJ. Scarlett, Amirsalar Rashidianfar, Christine Biben, Hans Zoellner, EmilyK. Colvin, JohnE. Pimanda, AndrewV. Biankin, Bin Zhou, WilliamT. Pu, OwenW.J. Prall, RichardP. Harvey. Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell, 2011; 9 (6): 527 DOI: 10.1016/j.stem.2011.10.002

Cite This Page:

Cell Press. "Newly discovered heart stem cells make muscle and bone." ScienceDaily. ScienceDaily, 24 January 2012. <www.sciencedaily.com/releases/2011/12/111201125139.htm>.
Cell Press. (2012, January 24). Newly discovered heart stem cells make muscle and bone. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2011/12/111201125139.htm
Cell Press. "Newly discovered heart stem cells make muscle and bone." ScienceDaily. www.sciencedaily.com/releases/2011/12/111201125139.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins