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Veterinarians find infections faster by monitoring blood compound; Blood test for dogs could lead to similar human test

Date:
December 6, 2011
Source:
University of Missouri-Columbia
Summary:
In pets and people, the time it takes to diagnose an infection may mean life or death. Now, a veterinarian is identifying ways to diagnose pet infections in approximately a third of the current diagnosis time.

Initial evaluation: Amy DeClue (right) and Kara Osterbur (left) performing an initial evaluation of a dog at University of Missouri Veterinary Medical Teaching Hospital Intensive Care Unit.
Credit: Image courtesy of University of Missouri-Columbia

In pets and people, the time it takes to diagnose an infection may mean life or death. Now, a University of Missouri veterinarian is identifying ways to diagnose pet infections in approximately a third of the current diagnosis time. The resulting test could be used eventually for humans.

"Infections can be difficult to diagnose, and many veterinarians have to send samples to a lab and wait three days or more as the lab attempts to grow a culture," said Amy DeClue, assistant professor of veterinary internal medicine in the MU College of Veterinary Medicine. "Meanwhile, the infection continues to spread each day that veterinarians wait on lab results, which is detrimental to the patient. In extreme infections, called sepsis, more than half of patients die. My group has been evaluating different blood biomarkers that could give a quick and accurate indication of infection, and we believe we've found a biomarker that will only require a simple blood test."

DeClue and her colleagues found that measuring the amount of the blood biomarker N-terminal portion of pro C-type natriuretic peptide (NT-pCNP) is a good indication of infection, and the same is true in humans. Working with collaborators at Veterinary Diagnostics Institute, DeClue hopes to develop a portable bedside test that veterinarians could use to quickly test patients for infection and ultimately target a better cure.

"In animal and human medicine, one goal is to reduce the amount of antibiotics used in treatment, to reduce bacterial resistance to antibiotics," DeClue said. "If successful, future tests could help veterinarians tailor treatment to the specific problem and reduce antibiotic use."

"The systems in dogs and people are very applicable to each other, so whatever biomarkers we find in dogs could also benefit people," DeClue said.

DeClue has tested several biomarkers for infection in dogs. "Evaluation of serum NT-pCNP as a diagnostic and prognostic biomarker for sepsis in dogs" was published in the May-June issue of the Journal of Veterinary Internal Medicine and "Plasma nitrate/nitrite concentrations in dogs with naturally developing sepsis and non-infectious forms of the systemic inflammatory response syndrome," was published in the November issue of the journal Veterinary Record. Co-authors include Kara Osterbur, a graduate student and emergency and critical care resident in the MU College of Veterinary Medicine.


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal References:

  1. A.E. DeClue, K. Osterbur, A. Bigio, C.R. Sharp. Evaluation of Serum NT-pCNP as a Diagnostic and Prognostic Biomarker for Sepsis in Dogs. Journal of Veterinary Internal Medicine, 2011; 25 (3): 453 DOI: 10.1111/j.1939-1676.2011.0713.x
  2. K. Osterbur, Z. Whitehead, C. R. Sharp, A. E. DeClue. Plasma nitrate/nitrite concentrations in dogs with naturally developing sepsis and non-infectious forms of the systemic inflammatory response syndrome. Veterinary Record, 2011; 169 (21): 554 DOI: 10.1136/vr.d5137

Cite This Page:

University of Missouri-Columbia. "Veterinarians find infections faster by monitoring blood compound; Blood test for dogs could lead to similar human test." ScienceDaily. ScienceDaily, 6 December 2011. <www.sciencedaily.com/releases/2011/12/111205140603.htm>.
University of Missouri-Columbia. (2011, December 6). Veterinarians find infections faster by monitoring blood compound; Blood test for dogs could lead to similar human test. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2011/12/111205140603.htm
University of Missouri-Columbia. "Veterinarians find infections faster by monitoring blood compound; Blood test for dogs could lead to similar human test." ScienceDaily. www.sciencedaily.com/releases/2011/12/111205140603.htm (accessed April 16, 2014).

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