Featured Research

from universities, journals, and other organizations

The biology behind severe PMS

Date:
December 21, 2011
Source:
Ume universitet
Summary:
Sensitivity to allopregnanolone, a hormone that occurs naturally in the body after ovulation and during pregnancy, changes during the course of the menstrual cycle and is different in women with severe PMS compared with women without PMS complaints.

Sensitivity to allopregnanolone, a hormone that occurs naturally in the body after ovulation and during pregnancy, changes during the course of the menstrual cycle and is different in women with severe pre-menstrual syndrome (PMS) compared with women without PMS complaints.

This has been shown by Erika Timby in her doctoral dissertation recently defended at Ume University, Sweden.

Women without mood changes prior to menstruation are more sensitive to allopregnanolone immediately after menstruation and less sensitive before. On the other hand, sensitivity to allopregnanolone in women who suffer from severe PMS with pronounced mood shifts ahead of every period is the opposite: these women are more sensitive before than after. This may mean that they have less ability to adapt to hormonal variations prior to menstruation.

It is unclear what causes this, however, but it may be that these individuals have an altered function in one of the brain's signal substance system, the so-called GABA system. The researchers indirectly measure the effect on the GABA system with the help of a special method that monitors the speed of eye movements when the subject follows a moving point of light.

In the studies women were given the endogenous substance allopregnanolone in doses that elevated the allopregnanolone in the blood to levels normally seen during pregnancy. A fatiguing effect was recorded in the form of slower eye movement and increased feeling of tiredness.

"We have studied few women, but this is one of the first studies to examine the effects of this particular metabolite from the corpus luteus hormone in humans. Greater knowledge of the underlying mechanisms of pronounced PMS can ultimately provide clues for new methods of treatment," says Erika Timby, a specialist physician at the Women's Clinic, Norrlands University Hospital in Ume and a doctoral candidate at the Department of Clinical Science, Unit for Obstetrics and Gynecology, Ume University.

Dissertation: Allopregnanolone effects in women. Clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use.


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Cite This Page:

Ume universitet. "The biology behind severe PMS." ScienceDaily. ScienceDaily, 21 December 2011. <www.sciencedaily.com/releases/2011/12/111221091722.htm>.
Ume universitet. (2011, December 21). The biology behind severe PMS. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/12/111221091722.htm
Ume universitet. "The biology behind severe PMS." ScienceDaily. www.sciencedaily.com/releases/2011/12/111221091722.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins