Featured Research

from universities, journals, and other organizations

Fixing common blood disorder would make kidney transplants more successful

Date:
December 22, 2011
Source:
American Society of Nephrology
Summary:
Correcting anemia, a red blood cell deficiency, can preserve kidney function in many kidney transplant recipients, according to a new study.

Correcting anemia, a red blood cell deficiency, can preserve kidney function in many kidney transplant recipients, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results indicate that aggressively treating anemia may help save the kidneys -- and possibly the lives -- of many transplant recipients.

Anemia commonly arises in patients with kidney disease because the kidneys secrete most of the hormone erythropoietin that stimulates red blood cell production. Anemia is also a common complication of kidney transplantation, with a prevalence of 25% to 40% after the first year.

Gabriel Choukroun, MD, PhD (CHU Amiens in France) and his colleagues initiated the Correction of Anemia and PRogression of Renal Insufficiency in Transplant patients (CAPRIT) study to see if the drug epoetin beta (a synthetic form of erythropoietin) could help preserve kidney function in kidney transplant recipients with anemia. Specifically, the investigators tested whether completely correcting anemia (by normalizing levels of hemoglobin, a blood component that carries oxygen) is better than partially correcting anemia.

During the study, 63 kidney transplant recipients took epoetin beta so that their hemoglobin levels remained in the normal range of 13.0 to 15.0 g/dL, while 62 patients took epoetin beta so that their hemoglobin levels hovered at a lower concentration of 10.5 to 11.5 g/dL.

Among the major findings after patients were treated for two years:

  • 4.8% of patients with completely corrected anemia developed kidney failure, compared with 21% of patients with partially corrected anemia.
  • 94.6% of transplanted kidneys in patients with completely corrected anemia were functional, compared with 80% in patients with partially corrected anemia.
  • Patients with completely corrected anemia experienced a significant improvement in quality of life at six and 12 months after starting therapy.

"This study shows that correction of anemia in kidney transplant recipients with anemia slows the progression of kidney failure and improves survival of transplanted kidneys," said Dr. Choukroun. Additional studies are needed to determine whether this also prolongs patients' lives.

Study co-authors include Nassim Kamar, Lionel Rostaing (CHU Toulouse); Bertrand Dussol (CHU Marseille); Isabelle Etienne (CHU Rouen); Elisabeth Cassuto-Viguier (CHU Nice); Olivier Toupance (CHU Reims); Franηois Glowacki (CHU Lille); Bruno Moulin (CHU Strasbourg); Yvon Lebranchu (CHU Tours); Guy Touchard (CHU Poitiers); Maοtι Jaureguy (CHU Amiens); Nicolas Pallet, Frank Martinez (CHU Necker); and Yannick Le Meur (CHU Brest).

Disclosures: The study was funded in part by a grant from Roche. Dr. Choukroun received honorarium from Roche for lectures and a grant for clinical research.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Choukroun, N. Kamar, B. Dussol, I. Etienne, E. Cassuto-Viguier, O. Toupance, F. Glowacki, B. Moulin, Y. Lebranchu, G. Touchard, M. Jaureguy, N. Pallet, Y. Le Meur, L. Rostaing, F. Martinez. Correction of Postkidney Transplant Anemia Reduces Progression of Allograft Nephropathy. Journal of the American Society of Nephrology, 2011; DOI: 10.1681/ASN.2011060546

Cite This Page:

American Society of Nephrology. "Fixing common blood disorder would make kidney transplants more successful." ScienceDaily. ScienceDaily, 22 December 2011. <www.sciencedaily.com/releases/2011/12/111222195004.htm>.
American Society of Nephrology. (2011, December 22). Fixing common blood disorder would make kidney transplants more successful. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/12/111222195004.htm
American Society of Nephrology. "Fixing common blood disorder would make kidney transplants more successful." ScienceDaily. www.sciencedaily.com/releases/2011/12/111222195004.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins