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Targeted blocking of cell death prevents fatal condition septic shock, study suggests

Date:
January 5, 2012
Source:
VIB
Summary:
Researchers have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. Researchers have described how blocking a particular form of cell death (necroptosis) fully protects mice against this fatal inflammation.

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition.

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In a new study in the journal Immunity, Peter Vandenabeele and colleagues of VIB-UGent described how blocking a particular form of cell death (necroptosis) fully protects mice against this fatal inflammation.

"This research opens up new perspectives for the treatment of fatal inflammatory diseases such as sepsis," says researcher Peter Vandenabeele of VIB and UGent. "By blocking necroptosis, we have found a possibly new target for a therapy."

Sepsis and SIRS

The Ghent scientists studied the Systemic Inflammatory Response Syndrome (SIRS). This is a severe inflammatory reaction affecting the entire body. It may be caused by an infection, such as sepsis, or by physical injury such as severe burns or a serious road accident.

Role of TNF in SIRS

The cytokine tumor necrosis factor (TNF) plays a crucial role in the occurrence of SIRS. The presence of TNF may trigger the cells to cause inflammation and programmed cell death. Inflammation is a necessary response in the body generated, among other things, to prevent or restore damage when injury and infections have been sustained. Programmed cell death can occur in two ways: via apoptosis or via necroptosis. The difference between the two forms of cell death lies among other things in communication with our immune system. Necroptosis usually provokes a strong reaction by the immune system whereas apoptosis proceeds unnoticed.

RIPK: Potential therapeutic target for treatment of SIRS and sepsis

Peter Vandenabeele and his colleagues Linde Duprez, Nozomi Takahashi and Anje Cauwels have discovered that in mice eliminating apoptosis did not have any impact on lethal SIRS whereas eliminating nepcroptosis afforded full protection against the condition. The scientists managed to block nepcroptosis by eliminating RIPK (Receptor-interacting serine/threonine-protein kinase) molecules. The experiments showed that RIPK plays a crucial role in SIRS and sepsis. The molecule appears to constitute a potential therapeutic target for the treatment of SIRS and sepsis. Further research should clarify the potential applications of this discovery.


Story Source:

The above story is based on materials provided by VIB. Note: Materials may be edited for content and length.


Journal Reference:

  1. Linde Duprez, Nozomi Takahashi, Filip VanHauwermeiren, Benjamin Vandendriessche, Vera Goossens, Tom VandenBerghe, Wim Declercq, Claude Libert, Anje Cauwels, Peter Vandenabeele. RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome. Immunity, 2011; 35 (6): 908 DOI: 10.1016/j.immuni.2011.09.020

Cite This Page:

VIB. "Targeted blocking of cell death prevents fatal condition septic shock, study suggests." ScienceDaily. ScienceDaily, 5 January 2012. <www.sciencedaily.com/releases/2011/12/111227092937.htm>.
VIB. (2012, January 5). Targeted blocking of cell death prevents fatal condition septic shock, study suggests. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2011/12/111227092937.htm
VIB. "Targeted blocking of cell death prevents fatal condition septic shock, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/12/111227092937.htm (accessed February 28, 2015).

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Scientists Identify Cell Death Pathway Involved in Lethal Sepsis

Dec. 22, 2011 Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Now, a new study finds that inhibition of a specific cell death pathway called ... read more

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