Featured Research

from universities, journals, and other organizations

Explaining heart failure as a cause of diabetes

Date:
January 19, 2012
Source:
Cell Press
Summary:
Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers appear to have found the culprit that leads from heart failure to diabetes and perhaps a novel way to break that metabolic vicious cycle.

Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart failure to diabetes and perhaps a novel way to break that metabolic vicious cycle.

"Our findings clarify the reasons why the incidence of heart failure is high among diabetic patients, why the prevalence of insulin resistance is increased in heart failure patients, and why treatment of insulin resistance improves the prognosis of heart failure patients," says Tohru Minamino of Chiba University Graduate School of Medicine.

It's a domino effect, the new evidence shows: the stress of heart failure activates the sympathetic nervous system. That stress response activates p53, which Minamino calls a cellular aging signal. That p53 signal ultimately leads to inflammation in fat tissue, systemic insulin resistance, and worsening heart function.

Of course, the protein p53 is probably best known as a tumor suppressor. "It has been reported that p53-dependent cellular aging is a protective mechanism for cancer development," Minamino says. But, he adds, constant activation of the anticancer signal can promote inflammation, cancer, and other diseases of aging.

Minamino had earlier shown that age-associated or stress-induced accumulation of p53 in the heart promotes heart failure. Aging and extra calories induce that same aging signal in fat tissue. Now it seems that activation of cardiac p53 also leads to activation of p53 in fat tissue. Those p53-dependent cellular aging signals in both tissues interact with each other, thereby accelerating the development of age-associated diseases, he says.

This suggests that an ideal treatment would block the inflammation that goes with p53's activation without compromising its tumor-fighting abilities. And for Minamino, that's the Holy Grail: an antiaging therapy without the cancer risk.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ippei Shimizu, Yohko Yoshida, Taro Katsuno, Kaoru Tateno, Sho Okada, Junji Moriya, Masataka Yokoyama, Aika Nojima, Takashi Ito, Rudolf Zechner, Issei Komuro, Yoshio Kobayashi, Tohru Minamino. p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure. Cell Metabolism, 2012; 15 (1): 51 DOI: 10.1016/j.cmet.2011.12.006

Cite This Page:

Cell Press. "Explaining heart failure as a cause of diabetes." ScienceDaily. ScienceDaily, 19 January 2012. <www.sciencedaily.com/releases/2012/01/120103135129.htm>.
Cell Press. (2012, January 19). Explaining heart failure as a cause of diabetes. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/01/120103135129.htm
Cell Press. "Explaining heart failure as a cause of diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103135129.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins