Featured Research

from universities, journals, and other organizations

Females may be more susceptible to infection during ovulation

Date:
January 4, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
A woman's ovarian cycle plays a role in susceptibility to infection, according to new research. Specifically, researchers found women are most susceptible to infection, such as Candida albicans or other sexually transmitted diseases, during ovulation than at any other time during the reproductive cycle. This natural "dip" in immunity may be to allow spermatozoa to survive the threat of an immune response so it may fertilize an egg successfully.

A new research report in the Journal of Leukocyte Biology suggests that a woman's ovarian cycle plays an important role in her susceptibility to infection. Specifically, researchers from Spain and Austria found that women are most susceptible to infection, such as Candida albicans or other sexually transmitted diseases, during ovulation than at any other time during the reproductive cycle. This natural "dip" in immunity may be to allow spermatozoa to survive the threat of an immune response so it may fertilize an egg successfully.

Related Articles


"This could be an explanation why during ovulation females have more risk of being infected with sexual transmitted diseases like HIV or HPV," said Miguel Relloso, Ph.D., a researcher involved in the work from the Laboratorio de Inmunobiología Molecular at the Hospital Gregorio Marañón and Complutense University in Madrid, Spain.

Using mice, Relloso and colleagues found that the sex hormone, estradiol, increased susceptibility to systemic candidiasis (fungal infection). To monitor the effect of estradiol treatment on infection, researchers used in vivo and ex vivo fungal infection models. Ovariectomized mice were treated with estradiol and subsequently pulsed with C. albicans. Estradiol-treated mice were more susceptible to the fungal infection and had lower Th17 immune response. The researchers identified dendritic cells as a target cells of estradiol and showed that estradiol treated dendritic cells were inefficient at triggering the Th17 immune response to C. albicans antigens.

"The next time you hear a woman say that she's sick of men," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "you can add this to her list as another reason. This adaption which allows male sperm to survive long enough to fertilize an egg, may also open the door for other types of infection."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Relloso, L. Aragoneses-Fenoll, S. Lasarte, C. Bourgeois, G. Romera, K. Kuchler, A. L. Corbi, M. A. Munoz-Fernandez, C. Nombela, J. L. Rodriguez-Fernandez, R. Diez-Orejas. Estradiol impairs the Th17 immune response against Candida albicans. Journal of Leukocyte Biology, 2011; 91 (1): 159 DOI: 10.1189/jlb.1110645

Cite This Page:

Federation of American Societies for Experimental Biology. "Females may be more susceptible to infection during ovulation." ScienceDaily. ScienceDaily, 4 January 2012. <www.sciencedaily.com/releases/2012/01/120103135333.htm>.
Federation of American Societies for Experimental Biology. (2012, January 4). Females may be more susceptible to infection during ovulation. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2012/01/120103135333.htm
Federation of American Societies for Experimental Biology. "Females may be more susceptible to infection during ovulation." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103135333.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins