Featured Research

from universities, journals, and other organizations

Greater brain activation after cognitive rehabilitation for MS

Date:
January 24, 2012
Source:
Kessler Foundation
Summary:
Scientists have documented increased cerebral activation in patients with multiple sclerosis following memory retraining using modified Story Memory Technique. This study is the first to demonstrate that behavioral interventions can have a positive effect on brain function in MS, an important step in validating the clinical utility of cognitive rehabilitation.

Neuroscientists at Kessler Foundation have documented increased cerebral activation in patients with multiple sclerosis (MS) following memory retraining using the modified Story Memory Technique (mSMT). This is the first study to demonstrate that behavioral interventions can have a positive effect on brain function in people with cognitive disability caused by MS, an important step in validating the clinical utility of cognitive rehabilitation.

Related Articles


According to Nancy Chiaravalloti, PhD, director of Neuropsychology & Neuroscience Research at Kessler Foundation, "This demonstrates that an effective cognitive rehabilitation protocol can lead to changes in the way the brain is actually processing information." Dr. Chiaravalloti is lead author of the article, which was published online by the Journal of Neurology on January 12.

Cognitive deficits are common in MS, though few studies have examined the efficacy of memory retraining in this population. Previous research conducted at Kessler Foundation demonstrated that mSMT improves new learning and memory in MS.

The new study utilized functional magnetic resonance imaging (fMRI) to document brain activation patterns before and after memory retraining. In the double-blind, placebo-controlled, randomized clinical trial, 16 individuals were randomly assigned to treatment (n = 8) or placebo (n = 8) groups. Each underwent 10 memory retraining sessions (twice weekly for 5 weeks). After treatment, greater activation was evident on fMRI in the treatment group during performance of a memory task; no change was seen in the placebo group. Increased activation was associated with improved memory performance. These benefits may warrant third-party reimbursement for this intervention in selected patients.

The article, Increased cerebral activation after behavioral treatment for memory deficits in MS, DOI: 10.1007/s00415-011-6353-x appeared online in the Journal of Neurology on January 12, 2012. Authors are Nancy Chiaravalloti, PhD, Glenn Wylie, DPhil, Victoria Leavitt, PhD, and John DeLuca, PhD, all of Kessler Foundation, West Orange, NJ. The authors also have faculty appointments with UMDNJ-New Jersey Medical School, Newark, NJ.

Research funded by National Institutes of Health grants RO1 HD045798 & HD45798-S, National MS Society and Kessler Foundation.


Story Source:

The above story is based on materials provided by Kessler Foundation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nancy D. Chiaravalloti, Glenn Wylie, Victoria Leavitt, John DeLuca. Increased cerebral activation after behavioral treatment for memory deficits in MS. Journal of Neurology, 2012; DOI: 10.1007/s00415-011-6353-x

Cite This Page:

Kessler Foundation. "Greater brain activation after cognitive rehabilitation for MS." ScienceDaily. ScienceDaily, 24 January 2012. <www.sciencedaily.com/releases/2012/01/120117145059.htm>.
Kessler Foundation. (2012, January 24). Greater brain activation after cognitive rehabilitation for MS. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2012/01/120117145059.htm
Kessler Foundation. "Greater brain activation after cognitive rehabilitation for MS." ScienceDaily. www.sciencedaily.com/releases/2012/01/120117145059.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

City Divided: A Look at Model Schools in the TDSB

City Divided: A Look at Model Schools in the TDSB

The Toronto Star (Jan. 27, 2015) Model schools are rethinking how they engage with the community to help enhance the lives of the students and their parents. Video provided by The Toronto Star
Powered by NewsLook.com
How Technology Is Ruining Snow Days For Students

How Technology Is Ruining Snow Days For Students

Newsy (Jan. 25, 2015) More schools are using online classes to keep from losing time to snow days, but it only works if students have Internet access at home. Video provided by Newsy
Powered by NewsLook.com
Weird Things Couples Do When They Lose Their Phone

Weird Things Couples Do When They Lose Their Phone

BuzzFeed (Jan. 24, 2015) Did you back it up? Do you even know how to do that? Video provided by BuzzFeed
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins