Featured Research

from universities, journals, and other organizations

Metastatic breast cancer hitches a free ride from the immune system

Date:
February 10, 2012
Source:
BioMed Central
Summary:
Inflammatory breast cancer (IBC) is the most lethal form of breast cancer . It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression.

Inflammatory breast cancer (IBC) is the most lethal form of breast cancer . It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research published in BioMed Central's open access journal Cell Communication and Signaling demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression.

Related Articles


Fibronectin is a cell-adhesion molecule which is usually involved in wound healing and cell migration during embryogenesis. Over-expression of this molecule is thought to allow cancer to metastasize. Prof Mona Mohamed from Cairo University used a cytokine antibody array to identify which immune-regulating molecules (cytokines, chemokines, and growth factors) were secreted by monocytes and found that, while monocytes secreted a small amount each of a wide range of molecules, there was up to 10 times more IL-8 and MCP-1.

The cocktail of immune-regulating molecules from the monocytes was able to increase the amount of fibronectin produced in IBC cells and in 3D culture produced branch-like structures typical of fibronectin over-expression. IL-8 on its own also turned up fibronectin expression in IBC cells. Prof Mohamed explained, "Adding IL-8 on its own to IBC cells caused an increase in the signaling proteins PI3K and AKT and it is this pathway which is responsible for fibronectin production."

The monocyte cocktail did not alter expression of another cell adhesion molecule, E-cadherin. Prof Mohamed continued, "From what we already knew about cell adhesion and these results, it seems that IBC cells are held together in clumps by E-cadherin, but fibronectin, and the IL-8 signaling pathway, are involved in branching and invasion necessary for metastasis of IBC."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mona M Mohamed. Monocytes conditioned media stimulate fibronectin expression and spreading of inflammatory breast cancer cells in three-dimensional culture: A mechanism mediated by IL-8 signaling pathway. Cell Communication and Signaling, 2012; 10 (1): 3 DOI: 10.1186/1478-811X-10-3

Cite This Page:

BioMed Central. "Metastatic breast cancer hitches a free ride from the immune system." ScienceDaily. ScienceDaily, 10 February 2012. <www.sciencedaily.com/releases/2012/02/120210111252.htm>.
BioMed Central. (2012, February 10). Metastatic breast cancer hitches a free ride from the immune system. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2012/02/120210111252.htm
BioMed Central. "Metastatic breast cancer hitches a free ride from the immune system." ScienceDaily. www.sciencedaily.com/releases/2012/02/120210111252.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins