Featured Research

from universities, journals, and other organizations

New insight into how 'chemical switch' that increases risk of stroke and heart disease risk is turned on

Date:
March 6, 2012
Source:
University of Leicester
Summary:
Scientists investigating a ‘biochemical switch’ linked to strokes and heart disease claim to have made an advance in understanding how it is ‘turned on’.

Model of the human P2X1 receptor for ATP, the three subunits that make up the functional receptor are shown in red, white and blue.
Credit: Image courtesy of University of Leicester

Scientists investigating a 'biochemical switch' linked to strokes and heart disease claim to have made an advance in understanding how it is 'turned on'.

The work was led by a team at the University of Leicester, working in collaboration with Cardiff University, to investigate the 'biochemical switch' identified as the P2X1 receptor.

Lead researcher Professor Richard Evans, of the University of Leicester Department of Cell Physiology & Pharmacology, said: "P2X1 receptors are protein molecules expressed on blood platelets which are cells involved in blood clotting. Drugs that block these receptors have the potential to reduce "dangerous" blood clotting that leads to strokes and heart attacks.

"Our research has looked at how the P2X1 receptor is "turned on." By biochemical studies and purifying the P2X1 receptor and using an electron microscope we have 'visualised' the receptor and detected changes in its shape when it is activated.

"The P2X1 receptor is made of three identical parts and we have shown that activation leads to these twisting against each-other. We found that if we chemically locked the receptor to stop this twisting, then the P2X1 receptor could not be fully activated.

"This is important as it gives the first realistic insight into how these novel receptors are turned on.

"This work will help to develop drugs that can stop the P2X1 receptor being "turned on" and would be useful to prevent stroke and heart attack."

The breakthrough was published in the Proceedings of the National Academy of Sciences. The research project was undertaken at the University of Leicester in the Department of Cell Physiology & Pharmacology and with Ralf Schmid in the University of Leicester Department of Biochemistry, along with Mark Young at Cardiff University. The study was funded by the Wellcome Trust and the British Heart Foundation.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. A. Roberts, R. C. Allsopp, S. El Ajouz, C. Vial, R. Schmid, M. T. Young, R. J. Evans. Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1201872109

Cite This Page:

University of Leicester. "New insight into how 'chemical switch' that increases risk of stroke and heart disease risk is turned on." ScienceDaily. ScienceDaily, 6 March 2012. <www.sciencedaily.com/releases/2012/03/120306072910.htm>.
University of Leicester. (2012, March 6). New insight into how 'chemical switch' that increases risk of stroke and heart disease risk is turned on. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2012/03/120306072910.htm
University of Leicester. "New insight into how 'chemical switch' that increases risk of stroke and heart disease risk is turned on." ScienceDaily. www.sciencedaily.com/releases/2012/03/120306072910.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins