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Protein discovery could switch off cardiovascular disease

Date:
March 12, 2012
Source:
Queen Mary, University of London
Summary:
Scientists have discovered a protein inside blood vessels with an ability to protect the body from substances which cause cardiovascular disease.

PXR in isolated human blood vessel cells.
Credit: Image courtesy of Queen Mary, University of London

Researchers from Queen Mary, University of London and the University of Surrey have found a protein inside blood vessels with an ability to protect the body from substances which cause cardiovascular disease.

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The findings, published online in the journal Cardiovascular Research, have revealed the protein protein pregnane X receptor (PXR) can switch on different protective pathways in the blood vessels.

Co-author Dr David Bishop-Bailey, based at Queen Mary's William Harvey Research Institute, said they found the protein was able to sense a wide variety of drugs, foreign chemicals and food products in the blood and switch on specific pathways to deal with them.

"We've known for a long time that this protein has an important role sorting out waste products in the liver -- now we believe it could have an important role in protecting the body against cardiovascular disease," he said.

Dr Karen Swales, based at the University of Surrey, said: "Heart and circulatory disease is the UK's biggest killer. Discovering that the protein pregnane X receptor (PXR) could protect blood vessels has major implications for the prevention of cardiovascular disease."

"We knew if PXR played similar protective roles in blood vessels to those in the liver, it could protect the vessels from damage caused by harmful substances in the blood."

The researchers used human tissue and blood vessel cells in culture and found PXR was present and active.

Dr Bishop-Bailey added: "We introduced specific PXR activating drugs and saw a co-ordinated increase in metabolising and anti-oxidant enzyme pathways.

"Since blood travels everywhere in the body, PXR has the potential to provide protection not just through its actions in the liver, but anywhere in the entire body. If we can work out how to manipulate PXR to turn on detoxification and antioxidant pathways in blood vessels, we may be a step closer to preventing our nation's biggest killer."


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. E. Swales, R. Moore, N. J. Truss, A. Tucker, T. D. Warner, M. Negishi, D. Bishop-Bailey. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovascular Research, 2011; 93 (4): 674 DOI: 10.1093/cvr/cvr330

Cite This Page:

Queen Mary, University of London. "Protein discovery could switch off cardiovascular disease." ScienceDaily. ScienceDaily, 12 March 2012. <www.sciencedaily.com/releases/2012/03/120312003226.htm>.
Queen Mary, University of London. (2012, March 12). Protein discovery could switch off cardiovascular disease. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2012/03/120312003226.htm
Queen Mary, University of London. "Protein discovery could switch off cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2012/03/120312003226.htm (accessed October 23, 2014).

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