Featured Research

from universities, journals, and other organizations

Antibiotic treatment increases the severity of asthma in young mice

Date:
March 19, 2012
Source:
European Molecular Biology Organization (EMBO)
Summary:
Treatment with the antibiotic vancomycin increases the severity of allergic asthma in young mice, researchers in Canada have revealed. The results are consistent with the “hygiene hypothesis” that links the loss of beneficial bacteria in the community of microorganisms in the gut, collectively known as the microbiota, to the onset of asthma.  

Treatment with the antibiotic vancomycin increases the severity of allergic asthma in young mice, researchers in Canada have revealed in a new study published in EMBO reports. The results are consistent with the "hygiene hypothesis" that links the loss of beneficial bacteria in the community of microorganisms in the gut, collectively known as the microbiota, to the onset of asthma.

Allergic asthma affects more than 100 million people worldwide and its prevalence is increasing, particularly among children in industrialized countries. Improved sanitation and widespread antibiotic use have been cited as possible reasons for the increase.

"We administered antibiotics to mice of different ages to determine if there was a link between the makeup of the microbial community in the gut and the extent of experimentally induced allergic asthma," said Dr. Brett Finlay, Professor at the Michael Smith Laboratories at the University of British Columbia, Canada. "Treatment of young mice with the antibiotic vancomycin reduced the diversity of microbes in the gut, significantly altered the composition of the bacterial population, and increased the susceptibility of young animals to experimentally induced asthma."

Many studies have suggested that the colonization of the gut early in life plays a substantial role in shaping the development of the immune system. More than 100 trillion bacteria, including more than 1000 bacterial species, colonize the human gut. If the balance of the microbial community in the gut is disrupted, the ability of the body to resist the onset of disease may be compromised.

Dr. Finlay remarked: "Although the precise link between the immune responses in the gut and lung remain unclear, we think that vancomycin selects for a community of microbes in the gut that somehow disrupts the inflammatory and regulatory immune responses at the two different sites. In mice, the restructuring of the intestinal microbial population during infancy after antibiotic treatment is enough to lead to exacerbated asthma."

The scientists used genome sequencing of the microbial population to reveal the diversity of the microbial community. The severity of asthma was assessed by different molecular assays and direct examination of lung tissue.

Said Finlay: "Our results confirm that the early months of life are a crucial time in which the gut microbial community may influence key immunological events that alter the sensitivity of the body's immune system to the response to allergens."

The work is part of the CIHR Canadian Microbiome Initiative, which was created to provide an opportunity for Canadian researchers to contribute to international efforts to understand the role of the human microbiome in health and disease.


Story Source:

The above story is based on materials provided by European Molecular Biology Organization (EMBO). Note: Materials may be edited for content and length.


Journal Reference:

  1. Shannon L Russell, Matthew J Gold, Martin Hartmann, Benjamin P Willing, Lisa Thorson, Marta Wlodarska, Navkiran Gill, Marie-Renιe Blanchet, William W Mohn, Kelly M McNagny, Brett B Finlay. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO reports, 2012; DOI: 10.1038/embor.2012.32

Cite This Page:

European Molecular Biology Organization (EMBO). "Antibiotic treatment increases the severity of asthma in young mice." ScienceDaily. ScienceDaily, 19 March 2012. <www.sciencedaily.com/releases/2012/03/120319094520.htm>.
European Molecular Biology Organization (EMBO). (2012, March 19). Antibiotic treatment increases the severity of asthma in young mice. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2012/03/120319094520.htm
European Molecular Biology Organization (EMBO). "Antibiotic treatment increases the severity of asthma in young mice." ScienceDaily. www.sciencedaily.com/releases/2012/03/120319094520.htm (accessed September 14, 2014).

Share This



More Health & Medicine News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) — The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) — A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) — Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) — The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins