Featured Research

from universities, journals, and other organizations

How colds cause coughs and wheezes

Date:
March 27, 2012
Source:
Society for General Microbiology
Summary:
Cold-like infections make 'cough receptors' in the airways more sensitive, making asthmatics more prone to bouts of coughing and wheezing, reveal scientists. The work could lead to drugs that reduce virus-induced coughing in those suffering chronic lung diseases.

Cold-like infections make 'cough receptors' in the airways more sensitive, making asthmatics more prone to bouts of coughing and wheezing, reveal scientists presenting their findings at the Society for General Microbiology's Spring Conference in Dublin. The work could lead to drugs that reduce virus-induced coughing in those suffering chronic lung diseases.

Related Articles


Asthmatics often report bouts of coughing, wheezing and breathlessness when they have a cold and there is no current medicine that sufficiently treats this problem. Researchers at Queen's University Belfast are investigating 'cough receptors' that line the cells of the airway and how these are affected by rhinovirus -- a virus frequently responsible for the common cold. The team showed that rhinovirus infection caused an increase in the number of these cough receptors- making the airways more sensitive.

Dr Hani'ah Abdullah, who is working on the project, explained how these receptors, called transient receptor potential (TRP) receptors, work. "TRP receptors respond to chemical and physical stimuli in the environment such as pollutants in the air, a change in air temperature and some of the toxic chemicals found in cigarette smoke. Once activated, these receptors cause the individual to cough and wheeze." she said.

Professor Louise Cosby and Dr Lorcan McGarvey from the Centre for Infection and Immunity, Queen's University Belfast, are jointly leading the research team of scientists and clinicians. Their group took airway cells from mild asthmatics and healthy individuals and infected them in the laboratory with rhinovirus, which is the most common virus to exacerbate symptoms of asthma. The results showed that rhinovirus infection caused an increase in the number of TRP receptors in the airway cells and that this effect was most pronounced in the mild asthmatics. "The increase in receptor numbers makes individuals more sensitive to environmental stimuli, making them more likely to suffer from prolonged bouts of coughing," explained Dr Abdullah.

The findings of this study may lead to new drugs that reduce virus-induced cough and wheeze in asthmatics and those with other chronic lung diseases. "It's feasible that therapies could be developed that block either the sensitivity of cough receptors or their increase in number. This would keep symptoms under control and ultimately improve the lives of asthmatics," said Dr Abdullah.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "How colds cause coughs and wheezes." ScienceDaily. ScienceDaily, 27 March 2012. <www.sciencedaily.com/releases/2012/03/120327094313.htm>.
Society for General Microbiology. (2012, March 27). How colds cause coughs and wheezes. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2012/03/120327094313.htm
Society for General Microbiology. "How colds cause coughs and wheezes." ScienceDaily. www.sciencedaily.com/releases/2012/03/120327094313.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins