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New method yields insulin-producing pancreatic cell clusters

Date:
April 4, 2012
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
Three-dimensional clusters of pancreatic beta-cells that live much longer and secrete more insulin than single cells grown in the laboratory are valuable new tools for studying pancreatic diseases such as diabetes and for testing novel therapies. Growing pancreatic cells in the laboratory is challenging, in part because to survive and function normally they require cell-cell contact.
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Three-dimensional clusters of pancreatic beta-cells that live much longer and secrete more insulin than single cells grown in the laboratory are valuable new tools for studying pancreatic diseases such as diabetes and for testing novel therapies. This cutting-edge advance is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc.

"Finding a solution for the culturing and final transplantation of pancreatic cells will be an enormous breakthrough for the treatment of diabetes," says John Jansen, DDS, PhD, Methods Co-Editor-in-Chief and Professor and Chairman, Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, The Netherlands.

Growing pancreatic cells in the laboratory is challenging, in part because to survive and function normally they require cell-cell contact. Abigail Bernard, Chien-Chi Lin, PhD, and Kristi Anseth, PhD, University of Colorado at Boulder, and Indiana University-Purdue University at Indianapolis, developed an innovative method that uses photolithography to create microwell cell culture environments that support the formation of 3-D pancreatic beta-cell clusters and control the size of the cell aggregates. They describe the ability to remove these cell clusters from the microwells and encapsulate them in hydrogels for subsequent testing or implantation.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Abigail B. Bernard, Chien-Chi Lin, Kristi S. Anseth. A Microwell Cell Culture Platform for the Aggregation of Pancreatic β-Cells. Tissue Engineering Part C: Methods, 2012; 120319094445005 DOI: 10.1089/ten.tec.2011.0504

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Mary Ann Liebert, Inc., Publishers. "New method yields insulin-producing pancreatic cell clusters." ScienceDaily. ScienceDaily, 4 April 2012. <www.sciencedaily.com/releases/2012/04/120404102138.htm>.
Mary Ann Liebert, Inc., Publishers. (2012, April 4). New method yields insulin-producing pancreatic cell clusters. ScienceDaily. Retrieved May 24, 2015 from www.sciencedaily.com/releases/2012/04/120404102138.htm
Mary Ann Liebert, Inc., Publishers. "New method yields insulin-producing pancreatic cell clusters." ScienceDaily. www.sciencedaily.com/releases/2012/04/120404102138.htm (accessed May 24, 2015).

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