Featured Research

from universities, journals, and other organizations

Scientists uncover potential treatment for painful side effect of diabetes

Date:
May 13, 2012
Source:
University of Warwick
Summary:
Why diabetics suffer from increased pain and temperature sensitivity is a step closer to being understood and effectively treated.

Why diabetics suffer from increased pain and temperature sensitivity is a step closer to being understood and effectively treated.

Related Articles


Research published in the journal Nature Medicine reveals that a multi-national collaboration between scientists from Warwick Medical School in the UK, and universities in Germany, New York, Australia and Eastern Europe, has discovered key information around one of the most distressing side effects of diabetes.

Painful diabetic neuropathy (PDN), which is abnormal and persistent pain experienced by roughly 50% of patients with diabetes, impairs patients' quality of life and affects sleep, mood, mobility, ability to work, relationships, self-esteem and independence.

Currently there is no clear understanding of how abnormal glucose metabolism produces heightened pain in diabetics, but this study offers vital new insights. The Warwick team of Dr Naila Rabbani and Professor Paul Thornalley have worked for 30 years on a reactive compound produced excessively from glucose in diabetes called methylglyoxal (MG). The new research led by Professors Angelika Bierhaus, Peter Nawroth and colleagues convincingly shows that MG is a new culprit in pain discomfort and, having pinpointed its relevance, further research is being undertaken to develop ways of inhibiting its activity and therefore reduce pain.

Professor Thornalley from the University of Warwick, explained:  “MG appears to attack and modify a key protein in the nerve endings called ‘Nav 1.8’ causing nerves to become super-sensitive to pain and extremes of temperature.  So diabetics typically develop a heightened sensitivity to hot and cold, accompanied with intense pain.

“This collaborative research indicates that using small peptides to ‘scavenge’ the problem-causing compound will lead to a reduction in pain and opens up new routes to develop accurate, targeted drug treatments to help diabetics.”

He added that an additional research programme at Warwick is currently investigating ways to increase the amount of an enzyme, glyoxalase 1 (Glo1), which removes MG catalytically.

“With global rates of diabetes increasing each year, our research is offering valuable insight into the science behind why glucose metabolism causes so many side effects and ultimately how we can develop treatments to improve patient care and outcomes.”


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Journal Reference:

  1. Angelika Bierhaus, Thomas Fleming, Stoyan Stoyanov, Andreas Leffler, Alexandru Babes, Cristian Neacsu, Susanne K Sauer, Mirjam Eberhardt, Martina Schnφlzer, Felix Lasischka, Winfried L Neuhuber, Tatjana I Kichko, Ilze Konrade, Ralf Elvert, Walter Mier, Valdis Pirags, Ivan K Lukic, Michael Morcos, Thomas Dehmer, Naila Rabbani, Paul J Thornalley, Diane Edelstein, Carla Nau, Josephine Forbes, Per M Humpert, Markus Schwaninger, Dan Ziegler, David M Stern, Mark E Cooper, Uwe Haberkorn, Michael Brownlee, Peter W Reeh, Peter P Nawroth. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nature Medicine, 2012; DOI: 10.1038/nm.2750

Cite This Page:

University of Warwick. "Scientists uncover potential treatment for painful side effect of diabetes." ScienceDaily. ScienceDaily, 13 May 2012. <www.sciencedaily.com/releases/2012/05/120513144533.htm>.
University of Warwick. (2012, May 13). Scientists uncover potential treatment for painful side effect of diabetes. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2012/05/120513144533.htm
University of Warwick. "Scientists uncover potential treatment for painful side effect of diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/05/120513144533.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) — Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) — Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) — As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) — A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins