Featured Research

from universities, journals, and other organizations

Mystery to the origin of long-lived, skin-deep immune cells uncovered

Date:
June 7, 2012
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Scientists have uncovered the origin of a group of skin-deep immune cells called the Langerhans cells, that act as the first line of defense against harmful germs and skin infections. Identifying the source of these sentry cells of the skin may hold exciting possibilities to novel strategies for vaccination and treatment of autoimmune diseases and inflammatory skin disorders.

Scientists at A*STAR's Singapore Immunology Network (SIgN) uncovered the origin of a group of skin-deep immune cells that act as the first line of defense against harmful germs and skin infections. SIgN scientists discovered that these sentry cells of the skin, called the Langerhans cells (LCs), originate from two distinct embryonic sites -- the early yolk sac and the fetal liver.

Related Articles


LCs are dendritic cells (DCs) found in the outermost layer of the skin. DCs are a critical component of the immune system because they are the only cells able to 'see' and 'alert' other responding immune cells to initiate a protective response against harmful foreign invaders. Like sentries of the immune system, DCs are strategically positioned where they are likely to encounter harmful pathogens. Identifying the source of these specialized immune cells may hold exciting possibilities to novel strategies for vaccination and treatment of autoimmune diseases and inflammatory skin disorders.

In contrast to other DCs which are constantly replaced by a circulating pool of bone marrow-derived precursors, LCs has the interesting ability to maintain themselves throughout life. While it is established that these long-lived sentry cells of the skin arise from precursors that are recruited to the skin prior to birth, this is the first time that the exact origin of the precursors of LCs is revealed through advanced fate-mapping technique (a method of tracing cell lineages to their embryonic origin).

In this study, published in the June issue of Journal of Experimental Medicine, Dr Florent Ginhoux, and his team demonstrated that adult LCs originate from two distinct embryonic lineages in two succeeding waves. The first wave of precursor cells from the yolk sac 'seed' the skin before the onset of the fetal liver. Interestingly, the team discovered that at the later stage of development, the yolk-sac precursors are largely replaced by a type of white blood cells from the fetal liver.

Said Dr Ginhoux, Principal Investigator of SIgN, "Whether this unique dual origin of Langerhans cells influences their ability to maintain skin integrity or dictate their specialized immune functions in response to microbes and vaccines needs to be examined. But having identified their origin surely opens new possibilities of using them as novel vaccination strategies or as therapeutic tool for treating inflammatory skin diseases like psoriasis."

Scientific Director of SIgN, Professor Paola Castagnoli said, "This discovery sheds light on understanding the complexities of the immune system, in particular the relationship between immune responses and human diseases. It will bring us closer to our goal of discovering novel ways of treating and preventing a range of immune diseases that will impact healthcare."


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. Hoeffel, Y. Wang, M. Greter, P. See, P. Teo, B. Malleret, M. Leboeuf, D. Low, G. Oller, F. Almeida, S. H. Y. Choy, M. Grisotto, L. Renia, S. J. Conway, E. R. Stanley, J. K. Y. Chan, L. G. Ng, I. M. Samokhvalov, M. Merad, F. Ginhoux. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. Journal of Experimental Medicine, 2012; 209 (6): 1167 DOI: 10.1084/jem.20120340

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "Mystery to the origin of long-lived, skin-deep immune cells uncovered." ScienceDaily. ScienceDaily, 7 June 2012. <www.sciencedaily.com/releases/2012/06/120607092859.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2012, June 7). Mystery to the origin of long-lived, skin-deep immune cells uncovered. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2012/06/120607092859.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "Mystery to the origin of long-lived, skin-deep immune cells uncovered." ScienceDaily. www.sciencedaily.com/releases/2012/06/120607092859.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins