Featured Research

from universities, journals, and other organizations

Regulating gluocse can prevent onset of Type 2 diabetes: Those with pre-diabetes can avoid progressing to diabetes

Date:
June 11, 2012
Source:
University of Colorado Denver
Summary:
People with pre-diabetes are significantly less likely to develop diabetes if their blood glucose levels are normalized in time, according to new research.

People with pre-diabetes are significantly less likely to develop the disease if their blood glucose levels are normalized in time, according to new research by the Colorado School of Public Health and University of Colorado School of Medicine.

The study was recently published in The Lancet.

"The importance of this analysis is clear," said Leigh Perreault, MD, a researcher with the CU School of Medicine and the Colorado School of Public Health. "Physicians should seek to restore normal glucose regulation in their patients with pre-diabetes."

The study shows that those at a high risk for Type 2 diabetes who experience a period of normal glucose regulation are 56 percent less likely to develop the disease 10 years later.

In 2011, the Centers for Disease Control and Prevention estimated that 79 million Americans or 35 percent of the population have pre-diabetes. Every year, approximately 11 percent go on to develop the disease, fueling the epidemic of Type 2 diabetes. Re-thinking prevention strategies in this group is critical to reducing overall disease rates.

Perreault, an associate professor of medicine and public health, conducted the research along with colleagues in the Diabetes Prevention Program Research Group. They used findings from the Diabetes Prevention Program Outcomes Study (DPPOS), a research effort examining long term outcomes in patients who took part in the Diabetes Prevention Program (DPP). The DPP studied over 3,000 patients with pre-diabetes.

Earlier analyses of the DPP and DPPOS data showed that lifestyle interventions and drug treatment can reduce the progression of pre-diabetes to diabetes. But the new research examines patients who not only avoided developing diabetes, but actually reverted to normal glucose function at some point during the study period.

These participants experienced a 56% reduction in progression to diabetes, regardless of how they reverted to normal glucose regulation even when it was only transitory.

The implications are significant for those planning diabetes reduction strategies who might now want to shift the standard of care to early and aggressive glucose-lowering treatments in patients at highest risk of developing Type 2 diabetes.

"Interventions that simply maintain pre-diabetes, even where overt diabetes is avoided short-term, are not enough as the long-term risk remains," Perreault said. "Strategies and follow-up should focus on achieving normal glucose regulation, by whatever means and however transient, to ensure the greatest reduction in diabetes risk for those with pre-diabetes."


Story Source:

The above story is based on materials provided by University of Colorado Denver. Note: Materials may be edited for content and length.


Journal Reference:

  1. Leigh Perreault, Qing Pan, Kieren J Mather, Karol E Watson, Richard F Hamman, Steven E Kahn. Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. The Lancet, 2012; DOI: 10.1016/S0140-6736(12)60525-X

Cite This Page:

University of Colorado Denver. "Regulating gluocse can prevent onset of Type 2 diabetes: Those with pre-diabetes can avoid progressing to diabetes." ScienceDaily. ScienceDaily, 11 June 2012. <www.sciencedaily.com/releases/2012/06/120611122542.htm>.
University of Colorado Denver. (2012, June 11). Regulating gluocse can prevent onset of Type 2 diabetes: Those with pre-diabetes can avoid progressing to diabetes. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2012/06/120611122542.htm
University of Colorado Denver. "Regulating gluocse can prevent onset of Type 2 diabetes: Those with pre-diabetes can avoid progressing to diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/06/120611122542.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins