Featured Research

from universities, journals, and other organizations

Improving high-tech medical scanners

Date:
June 13, 2012
Source:
National Institute of Standards and Technology (NIST)
Summary:
A powerful color-based imaging technique is making the jump from remote sensing to the operating room. Scientists are working to ensure it performs as well when spotting cancer cells in the body as it does with oil spills in the ocean.

Microarrayer machines (A) now can mix colors and deposit them on microscope slides, which can be used to calibrate hyperspectral imagers (HSI) for use in medical applications. The finished slides can be custom-colored (B) to calibrate HSIs to find specific types of tumors or disease tissue. Close up, they resemble dot-matrix printwork (C).
Credit: Clarke/NIST

A powerful color-based imaging technique is making the jump from remote sensing to the operating room -- and a team of scientists at the National Institute of Standards and Technology (NIST) have taken steps to ensure it performs as well when discerning oxygen-depleted tissues and cancer cells in the body as it does with oil spills in the ocean.

Microarrayer machines (A) now can mix colors and deposit them on microscope slides, which can be used to calibrate hyperspectral imagers (HSI) for use in medical applications. The finished slides can be custom-colored (B) to calibrate HSIs to find specific types of tumors or disease tissue. Close up, they resemble dot-matrix printwork (C). Credit: Clarke/NIST View hi-resolution image

The technique, called hyperspectral imaging (HSI), has frequently been used in satellites because of its superior ability to identify objects by color. While many other visual surveying methods can scan only for a single color, HSI is able to distinguish the full color spectrum in each pixel, which allows it to perceive the unique color "signatures" of individual objects. Well-calibrated HSI sensors have been able to discern problems from diseases in coral reefs to pollution in the atmosphere as determined by the distinct spectral signature at a location.

"Because diseased tissues and cells also have distinct spectra, scientists have been trying to use HSI for medical applications as well," says NIST physicist Jeeseong Hwang. "But any time you tell a machine to scan for something, you need to be sure it is actually looking for what you want, and you have to make sure that the image analysis algorithm extracts the correct color information out of a complex multicolor data set. We decided to create a way to calibrate an HSI device and to test its algorithm as well."

Matthew Clarke, a former National Research Council-supported postdoctoral fellow in Hwang's group who is currently working in the National Gallery of Art in Washington, D.C., wrote new software for a device called a microarrayer, so named because it is capable of laying down hundreds of tiny sample droplets in specific places on a microscope slide's surface. Normally a microarrayer creates DNA arrays for genetic research, but the team remade it into an artistic tool, programming it to select chemicals of different hues and lay them down on the slide's surface.

The results, which look a bit like dot-matrix printing, can be used to calibrate medical HSI devices and image analysis algorithms. When combined with HSI in a medical imaging application, this effort could allow a surgeon to look for cells with a specific chemical makeup, as determined by the cells' color.

"Scientists and engineers can create a custom slide with the exact colors representing the chemical makeup they want the HSI devices to detect," Hwang says. "It could be a good way to make sure the HSI devices for medical imaging perform correctly so that surgeons are able to see all of a tumor or diseased tissue when operating on a patient."

This project is part of a larger effort to evaluate and validate optical medical imaging devices, led by the NIST team members, David Allen, Maritoni Litorja, Antonio Possolo, Eric Shirley and Jeeseong Hwang. Hwang adds that the special issue of Biomedical Optics Express in which the team's findings appear is the output of a recent NIST-supported international workshop on the topic.


Story Source:

The above story is based on materials provided by National Institute of Standards and Technology (NIST). Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel V. Samarov, Matthew L. Clarke, Ji Youn Lee, David W. Allen, Maritoni Litorja, Jeeseong Hwang. Algorithm validation using multicolor phantoms. Biomedical Optics Express, 2012; 3 (6): 1300 DOI: 10.1364/BOE.3.001300

Cite This Page:

National Institute of Standards and Technology (NIST). "Improving high-tech medical scanners." ScienceDaily. ScienceDaily, 13 June 2012. <www.sciencedaily.com/releases/2012/06/120613153331.htm>.
National Institute of Standards and Technology (NIST). (2012, June 13). Improving high-tech medical scanners. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2012/06/120613153331.htm
National Institute of Standards and Technology (NIST). "Improving high-tech medical scanners." ScienceDaily. www.sciencedaily.com/releases/2012/06/120613153331.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins