Featured Research

from universities, journals, and other organizations

Metformin may lower cancer risk in people with type 2 diabetes

Date:
June 25, 2012
Source:
Endocrine Society
Summary:
A commonly prescribed diabetes drug, metformin, reduces the overall cancer risk in people with Type 2 diabetes, a large systematic review study finds.

A commonly prescribed diabetes drug, metformin, reduces the overall cancer risk in people with Type 2 diabetes, a large systematic review study finds. The results were presented June 25 at The Endocrine Society's 94th Annual Meeting in Houston.

Related Articles


"Type 2 diabetes increases the risk for several types of cancer," said lead author Diego Espinoza-Peralta, MD, an endocrinologist with Mexico's National Institute of Medical Sciences and Nutrition (Instituto Nacional de Ciencias Medicas y Nutricion) in Mexico City. "Our findings suggest that the regular use of metformin -- a low-cost medication -- reduces this risk, compared with not taking metformin."

Espinoza-Peralta and his colleagues conducted a systematic review and meta-analysis, or combined statistical analysis, of reported studies that evaluated cancer risk in patients with Type 2 diabetes. They analyzed seven relevant studies that included more than 32,400 Type 2 diabetic patients who had no other known condition that increased their cancer risk.

The investigators found that the odds of getting any type of cancer was 0.62 times less -- an estimated 38 percent relative risk reduction -- with daily continuous use of metformin than for those with no exposure to metformin.

"This risk reduction with metformin use extended to certain types of cancers, specifically colon and breast cancer," Espinoza-Peralta said.

Colorectal cancer and breast cancer are among the cancers that studies have found to occur more often in people with Type 2 diabetes. There was no risk reduction, however, in pancreatic cancer, another type of cancer for which people with Type 2 diabetes are at increased risk, the authors reported.

Metformin, which is the standard recommended initial treatment of Type 2 diabetes, may protect against cancer because it regulates activity of an enzyme that suppresses cell growth, according to Espinoza-Peralta.

"There is growing evidence that metformin brings more benefits to diabetic patients beyond glucose control," he said.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Metformin may lower cancer risk in people with type 2 diabetes." ScienceDaily. ScienceDaily, 25 June 2012. <www.sciencedaily.com/releases/2012/06/120625152308.htm>.
Endocrine Society. (2012, June 25). Metformin may lower cancer risk in people with type 2 diabetes. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2012/06/120625152308.htm
Endocrine Society. "Metformin may lower cancer risk in people with type 2 diabetes." ScienceDaily. www.sciencedaily.com/releases/2012/06/120625152308.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins