Featured Research

from universities, journals, and other organizations

Human insulin suppresses mosquito immune system: increasing cases of type II diabetes could abet malaria’s spread

Date:
June 26, 2012
Source:
American Society for Microbiology
Summary:
Human insulin suppresses the mosquito immune system, according to a new article. And while mosquitoes and malaria might seem to go together like baseball and hotdogs, mosquitoes' immunological resistance to the malaria parasite actually slows its spread among people.

Human insulin suppresses the mosquito immune system, according to a paper in the June Infection and Immunity. And while mosquitoes and malaria might seem to go together like baseball and hotdogs, mosquitoes' immunological resistance to the malaria parasite actually slows its spread among H. sapiens.

Related Articles


"A fair portion actually fight off the infection," says first author Nazzy Pakpour of the University of California, Davis.

But now the rate of type 2 diabetes is climbing in Africa as in most of the rest of the world, to the point where by 2030, one in five adults there are predicted to be so-afflicted. More diabetes means more hyperinsulinemia -- more human insulin to inhibit mosquitoes' immune response to Plasmodium falciparum, thus aiding and abetting transmission of this dread disease.

As horrific as the medical consequences of all this might be, the science is intriguing. "It's crazy to think something in our blood could change how mosquitoes respond to parasites," says Pakpour.

In earlier work, Pakpour and collaborators showed that ingested human insulin activates the insulin/IGF-1 signaling pathway in Anopheles stephensi mosquitoes, making them more vulnerable to invasion by P. falciparum. The new study showed that insulin signaling reduced expression of certain mosquito immunity genes that are under the same regulatory control, and that human insulin suppressed mosquito immunity by activating the so-called PI3K signaling pathway, and that artificially inhibiting that pathway could reverse the immunosuppressive effects of human insulin.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. Pakpour, V. Corby-Harris, G. P. Green, H. M. Smithers, K. W. Cheung, M. A. Riehle, S. Luckhart. Ingested Human Insulin Inhibits the Mosquito NF-B-Dependent Immune Response to Plasmodium falciparum. Infection and Immunity, 2012; 80 (6): 2141 DOI: 10.1128/IAI.00024-12

Cite This Page:

American Society for Microbiology. "Human insulin suppresses mosquito immune system: increasing cases of type II diabetes could abet malaria’s spread." ScienceDaily. ScienceDaily, 26 June 2012. <www.sciencedaily.com/releases/2012/06/120626061206.htm>.
American Society for Microbiology. (2012, June 26). Human insulin suppresses mosquito immune system: increasing cases of type II diabetes could abet malaria’s spread. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2012/06/120626061206.htm
American Society for Microbiology. "Human insulin suppresses mosquito immune system: increasing cases of type II diabetes could abet malaria’s spread." ScienceDaily. www.sciencedaily.com/releases/2012/06/120626061206.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins