Featured Research

from universities, journals, and other organizations

Transcription factor Lyl-1 critical in producing early T-cell progenitors

Date:
July 8, 2012
Source:
Baylor College of Medicine
Summary:
A transcription factor called Lyl-1 is necessary for production of the earliest cells that can become T-cells, critical cells born in the thymus that coordinate the immune response to cancer or infections, new research shows.

A transcription factor called Lyl-1 is necessary for production of the earliest cells that can become T-cells, critical cells born in the thymus that coordinate the immune response to cancer or infections, said a consortium of researchers led by those from Baylor College of Medicine in a report in the journal Nature Immunology.

These earliest progenitors (called early T lineage progenitor cells) are the first cells that can be identified as being on the road to becoming T-cells, said Dr. Margaret Goodell, director of the Stem Cells and Regenerative Medicine Center of Baylor College of Medicine. Without Lyl-1, only a few of these early T lineage progenitor cells get made.

"This finding gives us insight into the biology of these progenitor cells," said Goodell, a professor of pediatrics at BCM and a member of the Center for Cell and Gene Therapy at BCM, Texas Children¹s Hospital and The Methodist Hospital.

Dr. Fabian Zohren, a post-doctoral student in Goodell¹s laboratory, found that mice lacking the gene for this factor had a T-cell deficiency and in particular, too few of these early progenitor cells.

"It showed that those early T lineage progenitor cells are really dependent on Lyl-1 for their generation," said Goodell, who is also corresponding author of the report. "We think that Lyl-1 controls a program that allows survival and expansion of these critical progenitors."

The finding may have particular import in understanding a form of leukemia known as T-cell acute lymphoblastic leukemia. The researchers found that the forms of the disease that have the worst prognosis are those in which the cancer cells resemble these early T lineage progenitor cells. These cells also have high levels of Lyl-1.

One possibility is the T-cell progenitors in patients with this type of T-cell leukemia continue to express Lyl-1, so continue to be programmed to expand. The excess Lyl-1 prevents the early T lineage progenitor cells from differentiating into active T-cells. Goodell said a recent grant from the Alex¹s Lemonade Stand Foundation will help test that hypothesis.

Others who took part in this work include George P. Souroullas, Min Luo, Ulrike Gerdemann, Maria R. Imperato and Georgi L. Lukov, all of BCM; and Nicola K. Wilson and Berthold Göttgens of the University of Cambridge in the United Kingdom. Lukov is also with the Brigham Young University-Hawaii. Zohren was also with the Heinrich-Heine-University in Dusseldorf, Germany. Imperato is also with the University of Naples in Italy.

Funding for this work came from the National Institutes of Health, the Dan L. Duncan Cancer Center at BCM, the United Kingdom Medical Research Council, Leukemia and Lymphoma Research, the Dr. Mildred Scheel Foundation for Cancer Research and the Cancer Prevention and Research Institute of Texas.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fabian Zohren, George P Souroullas, Min Luo, Ulrike Gerdemann, Maria R Imperato, Nicola K Wilson, Berthold Göttgens, Georgi L Lukov, Margaret A Goodell. The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nature Immunology, 2012; DOI: 10.1038/ni.2365

Cite This Page:

Baylor College of Medicine. "Transcription factor Lyl-1 critical in producing early T-cell progenitors." ScienceDaily. ScienceDaily, 8 July 2012. <www.sciencedaily.com/releases/2012/07/120708162320.htm>.
Baylor College of Medicine. (2012, July 8). Transcription factor Lyl-1 critical in producing early T-cell progenitors. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2012/07/120708162320.htm
Baylor College of Medicine. "Transcription factor Lyl-1 critical in producing early T-cell progenitors." ScienceDaily. www.sciencedaily.com/releases/2012/07/120708162320.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) — The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins