Featured Research

from universities, journals, and other organizations

Obesity, metabolic factors linked to faster cognitive decline

Date:
August 20, 2012
Source:
American Academy of Neurology (AAN)
Summary:
People who are obese and also have high blood pressure and other risk factors called metabolic abnormalities may experience a faster decline in their cognitive skills over time than others, according to a new study.

People who are obese and also have high blood pressure and other risk factors called metabolic abnormalities may experience a faster decline in their cognitive skills over time than others, according to a study published in the August 21, 2012, print issue of Neurology, the medical journal of the American Academy of Neurology.

Metabolic abnormality was defined as having two or more of the following risk factors: high blood pressure or taking medication for it; low HDL or "good" cholesterol; high blood sugar or taking diabetes medication; and high triglycerides (a type of fat found in the blood) or taking medication to lower cholesterol.

The study involved 6,401 people with an average age 50 at the start of the study. Information on body mass index (BMI) and the risk factors was gathered at the beginning of the study. The participants took tests on memory and other cognitive skills three times over the next 10 years.

A total of 31 percent of the participants had two or more metabolic abnormalities. Nine percent were obese and 38 percent were overweight. Of the 582 obese people, 350, or 60 percent, met the criteria for metabolic abnormality. The metabolically normal obese individuals also experienced more rapid decline.

Over the 10 years of the study, people who were both obese and metabolically abnormal experienced a 22.5 percent faster decline on their cognitive test scores than those who were of normal weight without metabolic abnormalities.

"More research is needed to look at the effects of genetic factors and also to take into account how long people have been obese and how long they have had these metabolic risk factors and also to look at cognitive test scores spanning adulthood to give us a better understanding of the link between obesity and cognitive function, such as thinking, reasoning and memory," said study author Archana Singh-Manoux, PhD, of INSERM, the French research institute in Paris and University College London in England.

Singh-Manoux said the study also provides evidence against the concept of "metabolically healthy obesity" that has suggested that obese people without metabolic risk factors do not show negative cardiac and cognitive results compared to obese people with metabolic risk factors.

The study was supported by the National Institutes of Health, the Academy of Finland, the Bupa Foundation and the British Medical Research Council.


Story Source:

The above story is based on materials provided by American Academy of Neurology (AAN). Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Singh-Manoux, S. Czernichow, A. Elbaz, A. Dugravot, S. Sabia, G. Hagger-Johnson, S. Kaffashian, M. Zins, E. J. Brunner, H. Nabi, M. Kivimaki. Obesity phenotypes in midlife and cognition in early old age: The Whitehall II cohort study. Neurology, 2012; 79 (8): 755 DOI: 10.1212/WNL.0b013e3182661f63

Cite This Page:

American Academy of Neurology (AAN). "Obesity, metabolic factors linked to faster cognitive decline." ScienceDaily. ScienceDaily, 20 August 2012. <www.sciencedaily.com/releases/2012/08/120820160851.htm>.
American Academy of Neurology (AAN). (2012, August 20). Obesity, metabolic factors linked to faster cognitive decline. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/08/120820160851.htm
American Academy of Neurology (AAN). "Obesity, metabolic factors linked to faster cognitive decline." ScienceDaily. www.sciencedaily.com/releases/2012/08/120820160851.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins