Featured Research

from universities, journals, and other organizations

Kidney stones linked with small increased risk of later kidney problems

Date:
August 30, 2012
Source:
BMJ-British Medical Journal
Summary:
Kidney stones are associated with a small but significant increased risk of developing more serious kidney problems later in life, suggests a new study.

Kidney stones are associated with a small but significant increased risk of developing more serious kidney problems later in life, suggests a study published on bmj.com today.

Related Articles


Kidney stones are a common and often preventable condition in the general population, but their association with end stage renal disease or ESRD (commonly known as kidney failure) and other renal problems is unclear.

So a team of researchers in Canada and the USA set out to investigate whether the presence of kidney stones increase the risk of kidney failure or other adverse outcomes such as chronic kidney disease or raised blood creatinine levels (a sign that the kidneys are not working normally).

They tracked over three million patients for an average of 11 years. Hospital records were used to identify episodes of kidney stones and subsequent development of chronic kidney disease, kidney failure or raised creatinine levels.

A total of 23,706 (0.8%) patients had at least one kidney stone during follow-up, of whom 4% developed late stage chronic kidney disease, 6,581 (0.3%) experienced sustained doubling of creatinine levels and 5,333 (0.2%) developed kidney failure, compared with those without kidney stones.

In absolute terms, the rate of adverse renal outcomes associated with stones was small: 2.48 per million person days in people with one or more episodes of stones compared with 0.52 per million person days in people without stones (a "person day" is the number of days of follow-up multiplied by the number of people in the study).

The associations remained after adjusting for several other possible risk factors.

The excess risk associated with stones was greater in women than in men and among younger people than in those aged 50 years and over. However, the risks of all three adverse outcomes in those with at least one episode of stones were significantly higher than in those without stones in both sexes and age bands.

The authors suspect that the calcification process involved in the formation of kidney stones may be a possible cause of later renal damage, while obstruction leading to progressive scarring may also be a factor.

In conclusion, they say they found "a graded association between episodes of kidney stones and the risk of adverse renal outcomes, including ESRD." And they suggest that further research "should be aimed at determining the mechanisms explaining this association and assessing the optimal way to prevent kidney stones in the general population, especially young women."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. T. Alexander, B. R. Hemmelgarn, N. Wiebe, A. Bello, C. Morgan, S. Samuel, S. W. Klarenbach, G. C. Curhan, M. Tonelli. Kidney stones and kidney function loss: a cohort study. BMJ, 2012; 345 (aug29 2): e5287 DOI: 10.1136/bmj.e5287

Cite This Page:

BMJ-British Medical Journal. "Kidney stones linked with small increased risk of later kidney problems." ScienceDaily. ScienceDaily, 30 August 2012. <www.sciencedaily.com/releases/2012/08/120830191034.htm>.
BMJ-British Medical Journal. (2012, August 30). Kidney stones linked with small increased risk of later kidney problems. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2012/08/120830191034.htm
BMJ-British Medical Journal. "Kidney stones linked with small increased risk of later kidney problems." ScienceDaily. www.sciencedaily.com/releases/2012/08/120830191034.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins