Featured Research

from universities, journals, and other organizations

Broader approach provides new insight into diabetes genes

Date:
September 3, 2012
Source:
Lund University
Summary:
Using a new method, diabetes researchers have been able to reveal more of the genetic complexity behind type 2 diabetes. The new research findings have been achieved as a result of access to human insulin-producing cells from deceased donors and by not only studying one gene variant, but many genes and how they influence the level of the gene in pancreatic islets and their effect on insulin secretion and glucose control of the donor.

Using a new method, diabetes researchers at Lund University, Sweden, have been able to reveal more of the genetic complexity behind type 2 diabetes. The new research findings have been achieved as a result of access to human insulin-producing cells from deceased donors and by not only studying one gene variant, but many genes and how they influence the level of the gene in pancreatic islets and their effect on insulin secretion and glucose control of the donor.

Related Articles


"With this approach, we can explain 25 per cent of variations in blood sugar levels. Previously, the best studies have explained less than three per cent," says Leif Groop from Lund University Diabetes Centre, the principal author of the study, which has been published in the journal Cell Metabolism.

The findings of the study provide greater insight into why, in cases of type 2 diabetes, the insulin-producing beta cells cease to be able to perform their function of producing sufficient insulin to keep blood sugar levels under control. "We have linked different gene variants to their effect on donated human beta cells and have compared cells from non-diabetics and diabetics," says Professor Groop. The research team had access to cells from 63 donors, nine of whom had had type 2 diabetes.

The starting point for the work was the 47 known gene variants that have a statistical link to diabetes. "We used them as 'bait' to find new signal paths and chains of events where the 47 variants work together with other genes. We have to map patterns because a single gene rarely acts on its own," explains Leif Groop. Various criteria were used to sift out the 20 strongest gene variants. The criteria included a difference between beta cells from healthy individuals and diabetics and a link to insulin secretion and blood sugar levels. The majority of the 20 variants identified were not among the 47 known risk genes.

The central aim of the study is to understand why certain gene variants raise the risk of diabetes. "By taking a new and more holistic approach, we have gone a step further than previous projects and succeeded in linking together gene variants and their signal paths in human beta cells that cause reduced insulin secretion. The next step is to look in more detail at the way in which the strongest genes affect insulin secretion," says Leif Groop.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jalal Taneera, Stefan Lang, Amitabh Sharma, Joao Fadista, Yuedan Zhou, Emma Ahlqvist, Anna Jonsson, Valeriya Lyssenko, Petter Vikman, Ola Hansson, Hemang Parikh, Olle Korsgren, Arvind Soni, Ulrika Krus, Enming Zhang, Xing-Jun Jing, Jonathan L.S. Esguerra, Claes B. Wollheim, Albert Salehi, Anders Rosengren, Erik Renström, Leif Groop. A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets. Cell Metabolism, 2012; 16 (1): 122 DOI: 10.1016/j.cmet.2012.06.006

Cite This Page:

Lund University. "Broader approach provides new insight into diabetes genes." ScienceDaily. ScienceDaily, 3 September 2012. <www.sciencedaily.com/releases/2012/09/120903142955.htm>.
Lund University. (2012, September 3). Broader approach provides new insight into diabetes genes. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2012/09/120903142955.htm
Lund University. "Broader approach provides new insight into diabetes genes." ScienceDaily. www.sciencedaily.com/releases/2012/09/120903142955.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins