Featured Research

from universities, journals, and other organizations

Realizing the promise of RNA nanotechnology for new drug development

Date:
September 4, 2012
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
The use of RNA in nanotechnology applications is highly promising for many applications, including the development of new therapeutic compounds. Key technical challenges remain, though, and the challenges and opportunities associated with the use of RNA molecules in nanotechnology approaches are presented in a review article.

The use of RNA in nanotechnology applications is highly promising for many applications, including the development of new therapeutic compounds. Key technical challenges remain, though, and the challenges and opportunities associated with the use of RNA molecules in nanotechnology approaches are presented in a review article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc.

Peixuan Guo and colleagues, University of Kentucky, Lexington, highlight the ability of RNA to self-assemble into nanoparticles with diverse structures. In "Uniqueness, Advantages, Challenges, Solutions, and Perspectives in Therapeutics Applying RNA Nanotechnology," the authors provide a detailed description of the main challenges faced by the RNA therapeutics industry, including the chemical and thermodynamic instability of the molecules, potential safety and side effect issues, difficulties in delivery and specific targeting, and low yield and high production costs in manufacturing.

"The remarkable structural and enzymatic properties of RNA continue to astound us," says Executive Editor Fintan Steele, PhD, SomaLogic, Inc., Boulder, CO. "It is exciting to see those properties increasingly realized for the benefit of human health and welfare, as described by Dr. Guo and his colleagues."

Nucleic Acid Therapeutics is under the editorial leadership of Co-Editors-in-Chief Bruce A. Sullenger, PhD, Duke Translational Research Institute, Duke University Medical Center, Durham, NC, and C.A. Stein, MD, PhD, City of Hope National Medical Center, Duarte, CA; and Executive Editor Fintan Steele, PhD, SomaLogic, Boulder, CO.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peixuan Guo, Farzin Haque, Brent Hallahan, Randall Reif, and Hui Li. Uniqueness, Advantages, Challenges, Solutions, and Perspectives in Therapeutics Applying RNA Nanotechnology. Nucleic Acid Therapeutics, 2012, 22(4): 226-245 DOI: 10.1089/nat.2012.0350

Cite This Page:

Mary Ann Liebert, Inc., Publishers. "Realizing the promise of RNA nanotechnology for new drug development." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904144850.htm>.
Mary Ann Liebert, Inc., Publishers. (2012, September 4). Realizing the promise of RNA nanotechnology for new drug development. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2012/09/120904144850.htm
Mary Ann Liebert, Inc., Publishers. "Realizing the promise of RNA nanotechnology for new drug development." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904144850.htm (accessed September 21, 2014).

Share This



More Matter & Energy News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

What This MIT Sensor Could Mean For The Future Of Robotics

What This MIT Sensor Could Mean For The Future Of Robotics

Newsy (Sep. 20, 2014) MIT researchers developed a light-based sensor that gives robots 100 times the sensitivity of a human finger, allowing for "unprecedented dexterity." Video provided by Newsy
Powered by NewsLook.com
MIT BioSuit A New Take On Traditional Spacesuits

MIT BioSuit A New Take On Traditional Spacesuits

Newsy (Sep. 19, 2014) The MIT BioSuit could be an alternative to big, bulky traditional spacesuits, but the concept needs some work. Video provided by Newsy
Powered by NewsLook.com
New Music With Recycled Instruments at Colombia Fest

New Music With Recycled Instruments at Colombia Fest

AFP (Sep. 19, 2014) Jars, bottles, caps and even a pizza box, recovered from the trash, were the elements used by four musical groups at the "RSFEST2014 Sonorities Recycling Festival", in Colombian city of Cali. Duration: 00:49 Video provided by AFP
Powered by NewsLook.com
Virtual Reality Headsets Unveiled at Tokyo Game Show

Virtual Reality Headsets Unveiled at Tokyo Game Show

AFP (Sep. 18, 2014) Several companies unveiled virtual reality headsets at the Tokyo Game Show, Asia's largest digital entertainment exhibition. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins