Featured Research

from universities, journals, and other organizations

Some patients with common kidney disease can skip standard treatments

Date:
September 6, 2012
Source:
American Society of Nephrology (ASN)
Summary:
Many patients with a common kidney disease who had normal kidney function and only minor urinary abnormalities at diagnosis experienced remission without special treatments. None developed kidney failure over a 20-year follow-up.

For patients with a common kidney disease who have normal kidney function and only minor urinary abnormalities at the time of diagnosis, the long-term prognosis is excellent and no special treatments are needed, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings contrast with earlier, smaller studies and suggest that patients can avoid taking potentially toxic immunosuppressive medications often used to treat the disease.

IgA nephropathy occurs when antibodies build up in the kidneys, which can cause the kidneys to leak blood and proteins into the urine and in some cases can lead to kidney failure. But some patients with IgA nephropathy have normal kidney function and only minor urinary abnormalities at the time of diagnosis. The long-term prognosis of these patients is unclear.

To investigate, Eduardo Gutiérrez, MD, Manuel Praga, MD, PhD (Hospital Universitario 12 de Octubre, in Madrid), and their colleagues studied 141 Caucasian patients with biopsy-proven IgA nephropathy who had normal kidney function, little or no urinary protein leakage, or proteinuria, and who were not taking immunosuppressive medications for their disease.

Among the major findings:

  • After 10, 15, and 20 years, 96.7%, 91.9%, and 91.9% of patients maintained blood creatinine levels under a 50% increase from the start, respectively. (Rising creatinine levels indicate declining kidney function.) No patients developed kidney failure.
  • Clinical remission occurred in 53 (37.5%) patients after an average of four years.
  • 41 (29.1%) patients had no proteinuria.
  • At the start of the study, 23 (16.3%) patients had high blood pressure compared with 30 (21.3%) patients at the end of follow-up.
  • 59 (41.8%) patients were treated with medications that lower high blood pressure and proteinuria.

"We demonstrate that the long-term prognosis of this type of patient is excellent and that no special treatments other than those needed to lower blood pressure or treat increasing proteinuria are indicated," said Dr. Gutiérrez. "Our reassuring data are important because some previous studies had suggested that IgA nephropathy is a progressive disease even in this type of patient with benign presentation," he added.

Study co-authors include the following investigators in Spain: Isabel Zamora, MD, PhD, José Antonio Ballarín, MD, PhD, Yolanda Arce, MD, Sara Jiménez, MD, Carlos Quereda, MD, PhD, Teresa Olea, MD, Jorge Martínez-Ara, MD, PhD, Alfons Segarra, MD, PhD, Carmen Bernis, MD, PhD, Asunción García, MD, PhD, Marian Goicoechea, MD, PhD, Soledad García de Vinuesa, MD, PhD, and Jorge Rojas-Rivera, MD.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Eduardo Gutiérrez, Isabel Zamora, José Antonio Ballarín, Yolanda Arce, Sara Jiménez, Carlos Quereda, Teresa Olea, Jorge Martínez-Ara, Alfons Segarra, Carmen Bernis, Asunción García, Marian Goicoechea, Soledad García de Vinuesa, Jorge Rojas-Rivera, Manuel Praga, and for the Grupo de Estudio de Enfermedades Glomerulares de la Sociedad Española de Nefrología (GLOSEN). Long-Term Outcomes of IgA Nephropathy Presenting with Minimal or No Proteinuria. ournal of the American Society of Nephrology, 2012; DOI: 10.1681/ASN.2012010063

Cite This Page:

American Society of Nephrology (ASN). "Some patients with common kidney disease can skip standard treatments." ScienceDaily. ScienceDaily, 6 September 2012. <www.sciencedaily.com/releases/2012/09/120906181639.htm>.
American Society of Nephrology (ASN). (2012, September 6). Some patients with common kidney disease can skip standard treatments. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2012/09/120906181639.htm
American Society of Nephrology (ASN). "Some patients with common kidney disease can skip standard treatments." ScienceDaily. www.sciencedaily.com/releases/2012/09/120906181639.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) — Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins