Featured Research

from universities, journals, and other organizations

Surprising new roles for a key regulatory enzyme of blood pressure

Date:
September 8, 2012
Source:
Max Delbrück Center for Molecular Medicine
Summary:
Many patients with hypertension are treated with ACE inhibitors. These drugs block the angiotensin converting enzyme (ACE) that regulates the salt and water balance of the body and raises blood pressure. Recent studies, however, significantly broadened the enzyme's known task spectrum.

Many patients with hypertension are treated with ACE inhibitors. These drugs block the angiotensin converting enzyme (ACE) that regulates the salt and water balance of the body and raises blood pressure. Recent studies by a research team led by Professor Ken Bernstein (Cedars-Sinai Medical Center, Los Angeles, California, USA) have, however, significantly broadened the enzyme's known task spectrum: The enzyme also plays a key role in blood formation, renal development and male fertility. In addition, the researchers showed that ACE has a hitherto unexpected influence on the immune response.

Related Articles


At the 1st ECRC "Franz-Volhard" Symposium on Sept. 7, 2012 at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin-Buch, Professor Ken Bernstein reported that in mice an excess of ACE led to a much stronger immune response than usual. In animal experiments, not only could bacterial infections be combated more effectively, but also the growth of aggressive skin cancer (melanoma) in mice could be contained by a stronger response of the immune system. In contrast, if the mice lacked ACE, the immune cells worked less effectively.

In addition, ACE apparently has an influence on blood formation. It has been known for many years that, in humans, ACE inhibitors induce a small reduction of red blood cell levels. To elucidate the exact roles of ACE, the Bernstein's research team deactivated the genes in mice that normally provide the blueprint for the enzyme. As a consequence, these so-called "knock out" mice could no longer produce the enzyme. The examination of these mice revealed that they in fact had significantly fewer red blood cells. Also, the white blood cells in these animals were less functional. According to the researchers' studies, ACE evidently plays a role in the development of the different blood cells.

Bernstein's team also showed that ACE apparently plays an important role in the development of the kidneys. In mice that could not produce the enzyme, the small arteries and the tissue of the kidneys revealed pathological changes, and the urine flow was impaired.

According to these findings, male fertility is also associated with ACE. Male mice lacking ACE continued to produce sperm, but they were no longer able to reproduce. However, if in the mice not the enzyme itself, but rather a product of ACE -- namely the hormone angiotensin II -- was suppressed, they could continue to reproduce. Until now it was thought that ACE mainly exerts its effect through the production of angiotensin II. These results show, however, that ACE is enzymatically active and produces other active products apart from angiotensin II, for example in the testes.


Story Source:

The above story is based on materials provided by Max Delbrück Center for Molecular Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Max Delbrück Center for Molecular Medicine. "Surprising new roles for a key regulatory enzyme of blood pressure." ScienceDaily. ScienceDaily, 8 September 2012. <www.sciencedaily.com/releases/2012/09/120908081615.htm>.
Max Delbrück Center for Molecular Medicine. (2012, September 8). Surprising new roles for a key regulatory enzyme of blood pressure. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2012/09/120908081615.htm
Max Delbrück Center for Molecular Medicine. "Surprising new roles for a key regulatory enzyme of blood pressure." ScienceDaily. www.sciencedaily.com/releases/2012/09/120908081615.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins