Featured Research

from universities, journals, and other organizations

Brain neurons and diet influence onset of obesity and diabetes in mice

Date:
September 18, 2012
Source:
European Molecular Biology Organization
Summary:
The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers. The outcome, however, depends on the type of diet that the animals are fed.

The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed.
Credit: EMBO

The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed.

Related Articles


A lack of AgRP-neurons, brain cells known to be involved in the control of food intake, leads to obesity if mice are fed a regular carbohydrate diet. However, animals that are deficient in AgRP-neurons but which are raised on a high-fat diet are leaner and healthier. The differences are due to the influence of the AgRP-neurons on the way other tissues in the body break down and store nutrients. Mice lacking AgRP-neurons adapt poorly to a carbohydrate diet and their metabolism seems better suited for feeding on fat.

“Susceptibility to obesity and other metabolic diseases is mostly thought to be due to complex genetic interactions and the radical environmental changes that have occurred during the last century. However, it is not just a question of what you eat and your genetic makeup but also how the body manages to convert, store and use food nutrients,” commented Serge Luquet, lead author of the study and a researcher at the French Centre National de la Recherche Scientifique (CNRS) Unit of Functional and Adaptive Biology, Université Paris Diderot, Sorbonne Paris Cité.

The scientists wanted to show if a primary setting in the brain might directly affect the relative balance that exists in peripheral tissue between storage, conversion and utilization of carbohydrate and lipids. “The idea that we wanted to test in our experiments was whether the action of a specific type of brain cell known as the AgRP-neuron extended beyond its known influence on food intake. We found a new function for these cells, one that affects the communication with and activities of other tissues in the body including the liver, muscle and the pancreas,” added Luquet.

The researchers showed that mice that lacked AgRP-neurons from birth and which were fed on a regular carbohydrate diet had excessive body fat, increased amounts of the sugar-regulating hormone insulin, and normal levels of glucose in the blood. When the same animals were fed a high fat diet they showed a reduced gain in body weight and improved glucose clearance in the blood.

“Our work shows that central circuits in the brain that control food intake also control how nutrients are used in peripheral organs of the body,” remarked Luquet. “This further role for AgRP-neurons might represent a core mechanism linking obesity and obesity-related diseases.”

The prevalence of obesity and other metabolic diseases is increasing rapidly and effective and safe treatments are urgently needed. Obesity adversely affects health, decreases life expectancy, and increases the likelihood of other diseases including heart disease and type II diabetes. “Understanding the mechanisms by which the brain controls how nutrients are metabolized and stored in peripheral organs may prove essential to achieving a clinical breakthrough for these debilitating diseases,” added Luquet.


Story Source:

The above story is based on materials provided by European Molecular Biology Organization. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aurélie Joly-Amado, Raphaël G P Denis, Julien Castel, Amélie Lacombe, Céline Cansell, Claude Rouch, Nadim Kassis, Julien Dairou, Patrice D Cani, Renée Ventura-Clapier, Alexandre Prola, Melissa Flamment, Fabienne Foufelle, Christophe Magnan, Serge Luquet. Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning. The EMBO Journal, 2012; DOI: 10.1038/emboj.2012.250

Cite This Page:

European Molecular Biology Organization. "Brain neurons and diet influence onset of obesity and diabetes in mice." ScienceDaily. ScienceDaily, 18 September 2012. <www.sciencedaily.com/releases/2012/09/120918111633.htm>.
European Molecular Biology Organization. (2012, September 18). Brain neurons and diet influence onset of obesity and diabetes in mice. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2012/09/120918111633.htm
European Molecular Biology Organization. "Brain neurons and diet influence onset of obesity and diabetes in mice." ScienceDaily. www.sciencedaily.com/releases/2012/09/120918111633.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) — President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) — The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) — The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins