Featured Research

from universities, journals, and other organizations

Model confirms active surveillance as viable option for men with low-risk prostate cancer

Date:
September 24, 2012
Source:
American Association for Cancer Research (AACR)
Summary:

A new research model has estimated that the difference in prostate cancer mortality among men with low-risk disease who choose active surveillance versus those who choose immediate treatment with radical prostatectomy is likely to be very modest, possibly as little as two to three months.

The model, developed by biostatistician Ruth Etzioni, Ph.D., and colleagues of the Public Health Sciences Division at Fred Hutchinson Cancer Research Center in Seattle, Wash., is among the first to use specific data from published studies to project the likelihood of prostate cancer mortality among men with low-risk disease who choose active surveillance.

The study was published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"We are now diagnosing many more men with low-risk prostate cancer, a large fraction of whom would never have known they had disease in the absence of screening," Etzioni said. "These men have cancers that may not have caused them harm if they had not been detected through screening, and we are faced with the dilemma that not all of these men will benefit from treatment."

The alternative to treatment, known as watchful waiting or active surveillance, was backed by the National Institutes of Health as a viable option during a State-of-the-Science Consensus in December 2011. However, the approach is supported by little data due to the length of time required to measure its effect on prostate cancer mortality.

In this study, Etzioni and colleagues developed a simulation model to estimate prostate cancer mortality in men who would undergo active surveillance and compared that with the mortality of men treated with immediate radical prostatectomy. Using data from separate patient groups, they populated their model with time from diagnosis to treatment for men undergoing active surveillance, time from surgery to recurrence for men undergoing radical prostatectomy and time from recurrence after prostatectomy to death.

The model projected that 2.8 percent of men who undergo active surveillance would die from their disease within 20 years of their diagnosis compared with 1.6 percent of men who undergo immediate prostatectomy. The reduced risk for prostate cancer mortality by undergoing immediate radical prostatectomy amounted to an average of 1.8 months of additional life per patient. In comparison, those men who chose active surveillance would have an average of 6.4 years of life free from treatment and its side effects.

"Although this is not a new result, it is confirmation of what we expected and it substantiates data from previous studies looking at watchful waiting," Etzioni said. "Very few men with low-risk disease die from prostate cancer regardless, and the difference between treatments appears to be very modest."

It will be important to begin to measure quality of life between these two groups. Although immediate treatment is associated with both short-term and long-term side effects, including impotence and incontinence, active surveillance might also have an effect on a patient's quality of life.

"That six-year treatment-free interval means that men who choose active surveillance will not have to endure treatment side effects during that time, but whether that is replaced by a negative impact on quality of life because of anxiety or repeat biopsies is not well known," Etzioni said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research (AACR). Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Xia, B. J. Trock, M. R. Cooperberg, R. Gulati, S. B. Zeliadt, J. L. Gore, D. W. Lin, P. R. Carroll, H. B. Carter, R. Etzioni. Prostate Cancer Mortality following Active Surveillance versus Immediate Radical Prostatectomy. Clinical Cancer Research, 2012; DOI: 10.1158/1078-0432.CCR-12-1502

Cite This Page:

American Association for Cancer Research (AACR). "Model confirms active surveillance as viable option for men with low-risk prostate cancer." ScienceDaily. ScienceDaily, 24 September 2012. <www.sciencedaily.com/releases/2012/09/120924142144.htm>.
American Association for Cancer Research (AACR). (2012, September 24). Model confirms active surveillance as viable option for men with low-risk prostate cancer. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2012/09/120924142144.htm
American Association for Cancer Research (AACR). "Model confirms active surveillance as viable option for men with low-risk prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2012/09/120924142144.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins