Featured Research

from universities, journals, and other organizations

Macrophage accumulation of triglycerides yields insights into atherosclerosis

Date:
October 1, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
A new report helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function. Because a characteristic finding in atherosclerosis is the accumulation of fat in macrophages in the arterial wall, understanding how macrophages accumulate triglycerides may lead to new approaches toward slowing or stopping the development of atherosclerosis.

A research report appearing in the Journal of Leukocyte Biology helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function. Because a characteristic finding in atherosclerosis is the accumulation of fat in macrophages in the arterial wall, understanding how macrophages accumulate triglycerides may lead to new approaches toward slowing or stopping the development of atherosclerosis.

"Activation of macrophages leads to the accumulation of triglycerides in macrophages by multiple pathways that may have beneficial effects in host defense but could contribute to the accelerated atherosclerosis that occurs in chronic infections and inflammatory disease," said Kenneth R. Feingold, M.D., a researcher involved in the work from the Metabolism Section at the Veterans Affairs Medical Center in San Francisco, California. "By understanding the pathways that lead to this lipid accumulation in activated macrophages one might be able to manipulate these pathways to stimulate lipid accumulation to improve host defense or inhibit these pathways to reduce atherosclerosis depending on the clinical circumstances."

To make this discovery, scientists conducted laboratory experiments using a macrophage cell line, or mouse peritoneal macrophages. These cells were stimulated with various substances and the effect on macrophage glucose and fat metabolism was determined. They found that activated macrophages are more efficient at taking up glucose and use this glucose to synthesize fat. They also found that activated macrophages are more efficient at taking up fatty acids and use the fatty acids to synthesize triglycerides. Finally, the breakdown of fat (triglycerides) is decreased in activated macrophages. Together these changes in macrophage metabolism lead to the accumulation of fat inside the macrophage itself. The fact that multiple pathways are altered suggests that the accumulation of fat in activated macrophages is important to the function of activated macrophages.

"Drilling down to understand exactly how triglycerides are used by our body should ultimately help us better treatments for diseases such as atherosclerosis," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This report gives us important insights into how triglycerides accumulate in key immune cells involved in atherosclerosis and cardiovascular disease."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Parker, M. Dragunow, M. B. Hampton, A. J. Kettle, C. C. Winterbourn. Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus. Journal of Leukocyte Biology, 2012; 92 (4): 841 DOI: 10.1189/jlb.1211601

Cite This Page:

Federation of American Societies for Experimental Biology. "Macrophage accumulation of triglycerides yields insights into atherosclerosis." ScienceDaily. ScienceDaily, 1 October 2012. <www.sciencedaily.com/releases/2012/10/121001125235.htm>.
Federation of American Societies for Experimental Biology. (2012, October 1). Macrophage accumulation of triglycerides yields insights into atherosclerosis. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2012/10/121001125235.htm
Federation of American Societies for Experimental Biology. "Macrophage accumulation of triglycerides yields insights into atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2012/10/121001125235.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins