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New human neurons from adult cells right there in the brain

Date:
October 4, 2012
Source:
Cell Press
Summary:
Researchers have discovered a way to generate new human neurons from another type of adult cell found in our brains. The discovery is one step toward cell-based therapies for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's.

This is a direct observation of neuronal reprogramming of PDGFR-sorted pericyte-derived cells from the adult human brain by continuous live imaging in culture. Note the change in morphology of a cell coexpressing Sox2 and Mash1 (blue arrow) during reprogramming. Postimaging immunocytochemistry for III-tubulin (white) confirms the neuronal identity of the reprogrammed cell at the end of live imaging.
Credit: Cell Stem Cell, a Cell Press Journal, Karow et al.

Researchers have discovered a way to generate new human neurons from another type of adult cell found in our brains. The discovery, reported in the October 5th issue of Cell Stem Cell, a Cell Press publication, is one step toward cell-based therapies for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's.

"This work aims at converting cells that are present throughout the brain but themselves are not nerve cells into neurons," said Benedikt Berninger, now at the Johannes Gutenberg University Mainz. "The ultimate goal we have in mind is that this may one day enable us to induce such conversion within the brain itself and thus provide a novel strategy for repairing the injured or diseased brain."

The cells that made the leap from one identity to another are known as pericytes. Those cells, found in close association with the blood vessels, are important for keeping the blood-brain barrier intact and have been shown to participate in wound healing in other parts of the body.

"Now, we reason, if we could target these cells and entice them to make nerve cells, we could take advantage of this injury response," Berninger says.

Further testing showed that those newly converted neurons could produce electrical signals and reach out to other neurons, providing evidence that the converted cells could integrate into neural networks.

"While much needs to be learnt about adapting a direct neuronal reprogramming strategy to meaningful repair in vivo, our data provide strong support for the notion that neuronal reprogramming of cells of pericytic origin within the damaged brain may become a viable approach to replace degenerated neurons," the researchers write.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marisa Karow, Rodrigo Sánchez, Christian Schichor, Giacomo Masserdotti, Felipe Ortega, Christophe Heinrich, Sergio Gascón, Muhammad A. Khan, D. Chichung Lie, Arianna Dellavalle, Giulio Cossu, Roland Goldbrunner, Magdalena Götz, Benedikt Berninger. Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells. Cell Stem Cell, 2012; 11 (4): 471 DOI: 10.1016/j.stem.2012.07.007

Cite This Page:

Cell Press. "New human neurons from adult cells right there in the brain." ScienceDaily. ScienceDaily, 4 October 2012. <www.sciencedaily.com/releases/2012/10/121004121540.htm>.
Cell Press. (2012, October 4). New human neurons from adult cells right there in the brain. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/10/121004121540.htm
Cell Press. "New human neurons from adult cells right there in the brain." ScienceDaily. www.sciencedaily.com/releases/2012/10/121004121540.htm (accessed September 2, 2014).

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