Featured Research

from universities, journals, and other organizations

New function of protein involved in colon cancer identified

Date:
October 4, 2012
Source:
IMIM (Hospital del Mar Medical Research Institute)
Summary:
Researchers have determined the function of a new variant of enzyme IKKalpha (IKK±) is to activate some of the genes taking part in the tumor progressions of colorectal cancer. In the future, this knowledge will make it possible to design new drugs that inhibit this enzyme specifically and are less toxic for the remaining body cells, hence improving the treatment for this disease.

Researchers from IMIM, Hospital del Mar Medical Research Institute, have succeeded in determining the function of a new variant of enzyme IKKalpha (IKKα) to activate some of the genes taking part in the tumor progressions of colorectal cancer. In the future, this knowledge will make it possible to design new drugs that inhibit this enzyme specifically and are less toxic for the remaining body cells, hence improving the treatment for this disease.

The study is the culmination of previous research by the IMIM Research Group on Stem Cells and Cancer that had demonstrated the existence of a link between the activation of the IKKα enzyme and occurrence of colorectal cancer in humans. "We studied the particularities that distinguish the pre-tumor activity of IKKα from its normal physiological activities, which are known to be essential for the survival of non-cancerous cells and can therefore not be pharmacologically inhibited without causing great harm to the body" explains Dr. Lluís Espinosa, a member of the group and the director of this study.

IKKα is a specific type of enzyme, known as kinase. These enzymes are proteins that act on other proteins adding to them a phosphate and thus modifying their function. The p45-IKKα, which we identified, is located in the nucleus of cancer cells and their action is essential for the progression of the tumor. Lluís Espinosa adds: "The most important novelty of our findings is the identification of a new form of the IKKα kinase, which is mainly involved in activating genes that take part in the tumor progression, and that differs from the main activity of this kinase in normal cells."

For this research a total of 288 human samples of colorectal cancer were analyzed, identifying the presence of p45-IKKα in most of them and proving that specifically blocking this new form of IKKα avoids the growth of this particular cancer cells.

The results of this work open the door to multiple research lines aiming to discover the mechanisms that generate and activate this p45-IKKα enzyme, and identifying possible inhibitors that are more effective against tumor cells, that are less toxic for the remaining body cells. However, it is important to note that while these results represent an important advance towards understanding the mechanisms of tumor progression, further research will be needed before considering future therapeutic applications of this type of drugs in patients with colorectal cancer.


Story Source:

The above story is based on materials provided by IMIM (Hospital del Mar Medical Research Institute). Note: Materials may be edited for content and length.


Journal Reference:

  1. Pol Margalef, Vanessa Fernández-Majada, Alberto Villanueva, Ricard Garcia Carbonell, Mar Iglesias, Laura López, María Martínez-Iniesta, Jordi Villà-Freixa, Mari Carmen Mulero, Montserrat Andreu, Ferran Torres, Marty W Mayo, Anna Bigas, Lluis Espinosa. A novel truncated form of IKK is responsible for specific nuclear IKKα activity in Colorectal Cancer. Cell Reports, 2012

Cite This Page:

IMIM (Hospital del Mar Medical Research Institute). "New function of protein involved in colon cancer identified." ScienceDaily. ScienceDaily, 4 October 2012. <www.sciencedaily.com/releases/2012/10/121004121554.htm>.
IMIM (Hospital del Mar Medical Research Institute). (2012, October 4). New function of protein involved in colon cancer identified. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2012/10/121004121554.htm
IMIM (Hospital del Mar Medical Research Institute). "New function of protein involved in colon cancer identified." ScienceDaily. www.sciencedaily.com/releases/2012/10/121004121554.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins