Featured Research

from universities, journals, and other organizations

Tau drug heads into phase 3 trials in frontotemporal dementia, Alzheimer's

Date:
October 5, 2012
Source:
Alzheimer Research Forum Foundation
Summary:
A small company with roots in Singapore and Scotland plans to test a relatively unknown compound in clinical trials for a type of dementia that strongly affects behavior.

Remberฎ -- the blue dye that created a stir in 2008 when Phase 2 clinical trial data claimed that it slowed decline in people with Alzheimer's disease -- has now been revamped for Phase 3 testing in another disease, behavioral-variant frontotemporal dementia (bvFTD).

Related Articles


TauRx Therapeutics, a Singaporean-Scottish biotech company, reformulated Remberฎ to improve absorption and tolerability, and will test its modified oral compound, LMTX, in bvFTD patients at 25 to 30 sites worldwide. Pending ethics review and approvals, the 12-month bvFTD trial is expected to begin enrolling in November or December. The company also plans to launch two Phase 3 trials in AD in late 2012.

The TauRx molecule has roused researchers' curiosity on a number of fronts. It is believed to be the only drug in clinical testing that breaks up aggregates of tau, the protein that forms neurofibrillary tangles in Alzheimer's and other neurodegenerative diseases. Even more unusual, it has reached Phase 3 with hardly any published preclinical data. Aside from several talks and posters presented at the International Conferences on Alzheimer's Disease in Chicago and Vienna, which Alzforum reported in 2008 and 2009, very little data on Rember or LMTX is in the public domain. Moreover, scientists had concerns about the design and analysis of the company's earlier Phase 2 trial in AD, some of which are addressed in the upcoming Phase 3 studies. A recent Alzforum story and Q&A with TauRx CEO Claude Wischik describe these developments.


Story Source:

The above story is based on materials provided by Alzheimer Research Forum Foundation. Note: Materials may be edited for content and length.


Cite This Page:

Alzheimer Research Forum Foundation. "Tau drug heads into phase 3 trials in frontotemporal dementia, Alzheimer's." ScienceDaily. ScienceDaily, 5 October 2012. <www.sciencedaily.com/releases/2012/10/121005134627.htm>.
Alzheimer Research Forum Foundation. (2012, October 5). Tau drug heads into phase 3 trials in frontotemporal dementia, Alzheimer's. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2012/10/121005134627.htm
Alzheimer Research Forum Foundation. "Tau drug heads into phase 3 trials in frontotemporal dementia, Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2012/10/121005134627.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) — Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) — A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com
Researchers Replace Damaged Hands With Prostheses

Researchers Replace Damaged Hands With Prostheses

Newsy (Feb. 25, 2015) — Scientists in Austria have been able to fit patients who&apos;ve lost the use of a hand with bionic prostheses the patients control with their minds. Video provided by Newsy
Powered by NewsLook.com
Couple Leaving Everything in Will to Pet Monkey

Couple Leaving Everything in Will to Pet Monkey

Buzz60 (Feb. 20, 2015) — After being kicked out of their families for marrying against their wishes, an Indian couple is leaving their house, land and savings to their pet monkey when they die. Patrick Jones (@Patrick_E_Jones) explains. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins