Featured Research

from universities, journals, and other organizations

With a little exercise, your fat cells may coax liver to produce 'good' cholesterol

Date:
October 9, 2012
Source:
Methodist Hospital, Houston
Summary:
With a little exercise and dieting, overweight people with type 2 diabetes can still train their fat cells to produce a hormone believed to spur HDL cholesterol production, report medical researchers.

With a little exercise and dieting, overweight people with type 2 diabetes can still train their fat cells to produce a hormone believed to spur HDL cholesterol production, report medical researchers from The Methodist Hospital and eight other institutions in an upcoming issue of the Journal of Lipid Research (now online).

"What we're learning is that even overweight people who are physically active and eating a healthy diet are getting benefits from the lifestyle change," said principal investigator Christie Ballantyne, M.D., director of Methodist's Center for Cardiovascular Disease Prevention. "When you exercise and diet, you're improving the function of your adipose tissue, your heart and vascular systems, and even muscle performance. You're getting a lot of benefits that you may not see by just looking at the weight on a scale."

The Center for Cardiovascular Disease Prevention is part of the Methodist DeBakey Heart & Vascular Center.

Ballantyne said that while a causal relationship between adiponectin production and increases in blood HDL cholesterol levels is not yet proven, this latest study supports models putting the fat hormone somewhere in the controlling pathway of liver HDL cholesterol synthesis. Adiponectin's role in fat burning and sugar storage is well established.

Ballantyne and his team examined patient data from Look AHEAD, a project intended to clarify the relationship between obesity, diabetes, and cardiovascular disease. Look AHEAD is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). To be eligible for Look AHEAD, participants must have been diagnosed with type 2 diabetes, and also deemed overweight or obese. Enrollees consent to an "intenstive lifestyle intervention" in which they become more physically active and limit their calorie intake.

Look AHEAD participants have had their blood drawn at regular intervals, with testing for various biomarkers, including HDL cholesterol and the fat hormone adiponectin, in its many forms. Study participants are also weighed and given a fitness (exercise stress) test.

After one year, Look AHEAD participants' adiposity (a measure of total fat), fitness, blood glucose levels, and fat levels were, on average, significantly improved. Levels of LDL, the so-called "bad cholesterol," did not change. But Adiponectin levels and HDL cholesterol did. Total adiponectin produced by fat cells increased about 12 percent relative to a control group, in which people received diabetes and obesity education but no intensive lifestyle modification. And HDL cholesterol went up nearly 10 percent.

HDL cholesterol correlates positively with overall cardiovascular health. It is not yet known for sure whether low HDL cholesterol causes cardiovascular problems, or whether both (low HDL and CV problems) are controlled in parallel by another, as-yet-unknown effector.


Story Source:

The above story is based on materials provided by Methodist Hospital, Houston. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. M. Belalcazar, W. Lang, S. M. Haffner, R. C. Hoogeveen, F. X. Pi-Sunyer, D. C. Schwenke, A. Balasubramanyam, R. P. Tracy, A. P. Kriska, C. M. Ballantyne. Adiponectin and the mediation of HDL cholesterol change with improved lifestyle: The Look AHEAD Study. The Journal of Lipid Research, 2012; DOI: 10.1194/jlr.M030213

Cite This Page:

Methodist Hospital, Houston. "With a little exercise, your fat cells may coax liver to produce 'good' cholesterol." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009111204.htm>.
Methodist Hospital, Houston. (2012, October 9). With a little exercise, your fat cells may coax liver to produce 'good' cholesterol. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/10/121009111204.htm
Methodist Hospital, Houston. "With a little exercise, your fat cells may coax liver to produce 'good' cholesterol." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009111204.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins