Featured Research

from universities, journals, and other organizations

Non-genetic factors play role in non-diabetic kidney disease among African-Americans

Date:
October 9, 2012
Source:
Wake Forest Baptist Medical Center
Summary:
The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease.

The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease.

Researchers at Wake Forest Baptist Medical Center are working to find out why.

In a study published in the October issue of the journal Kidney International, the research team evaluated children and siblings of African-Americans on dialysis to determine why some develop kidney disease and others don't. These relatives of the dialysis patients are more likely to inherit the variance in the apolipoprotein L1 (APOL1) gene than members of the general population.

APOL1 gene mutations are associated with up to 40 percent of kidney disease in African- Americans who are treated with dialysis or receive a kidney transplant. This genetic association, which was discovered in 2010 by a team of researchers including Barry Freedman, M.D. professor of nephrology at Wake Forest Baptist, is one of the strongest ever detected for a common disease and helps explain the higher rates of non-diabetic kidney disease among African- Americans relative to the general population.

In this study, the researchers screened 786 close relatives from 470 African-American families with a member who had non-diabetic kidney failure and underwent dialysis. Of the relatives screened, 23 percent had two copies of the gene variant, 47 percent had one copy and 30 percent had no copies. In the general African-American population, the corresponding figures are 12, 39 and 49 percent, respectively.

After adjusting for familial relationships, the researchers found that kidney function, blood pressure and protein in the urine were not significantly different among those with two copies of the variant as compared to those with one or no copies. Weak APOL1 associations with kidney disease were observed after adjusting for age, gender, family age at dialysis and ancestry.

Freedman, the lead author of the study, said the researchers had expected to find a far greater effect of the gene on mild kidney disease in the relatives who had two copies of the variant.

"If the gene alone isn't the trigger, then what is?" he said. "Modifying factors or 'second hits', such as viral infections or environmental factors, must be present to cause kidney disease. More research needs to be conducted in order to identify them.

"We can't change someone's genetic makeup, but if we can find out what the 'second hits' are then hopefully we can find ways to block them and protect people from kidney disease." The researchers also concluded that there may be limited value in broadly screening African-Americans for this gene variant to detect those with mild kidney disease. This recommendation may change when modifiable second hits are identified, Freedman said. In addition, there may be value in screening certain individuals, particularly relatives of African-American patients on dialysis who may want to donate a kidney.

Co-authors of the study are Carl D. Langefeld, Ph.D., JoLyn Turner, Ph.D., Marina Nunez, M.D., Ph.D., Kevin P. High, M.D., Mitzie Spainhour, L.P.N., Pamela J. Hicks, B.S., Donald W. Bowden, Ph.D., Amber M. Reeves-Daniel, M.D., Mariana Murea,M.D., Michael V. Rocco, M.D., and Jasmin Divers, Ph.D., of Wake Forest Baptist.

The study was supported by the National Institutes of Health grants RO1HL56266, RO1DK070941 and RO1DK084149.


Story Source:

The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest Baptist Medical Center. "Non-genetic factors play role in non-diabetic kidney disease among African-Americans." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009111206.htm>.
Wake Forest Baptist Medical Center. (2012, October 9). Non-genetic factors play role in non-diabetic kidney disease among African-Americans. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2012/10/121009111206.htm
Wake Forest Baptist Medical Center. "Non-genetic factors play role in non-diabetic kidney disease among African-Americans." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009111206.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins