Featured Research

from universities, journals, and other organizations

Astrocytes as a novel target in Alzheimer’s disease

Date:
October 10, 2012
Source:
Expertsvar
Summary:
Alzheimer’s disease is a severe neurodegenerative disease that affects 45% of people over 85 years of age. Medical researchers have now identified astrocytes as a novel target for the development of future treatment strategies.

Alzheimer's disease is a severe neurodegenerative disease that affects 45% of people over 85 years of age. The research teams of Prof. Jin-Moo Lee at Washington University in Saint Louis, USA, and Prof. Milos Pekny at Sahlgrenska Academy in Gothenburg, Sweden, have identified astrocytes as a novel target for the development of future treatment strategies.

The results have just been published in the FASEB Journal.

Astrocytes are known as cells that control many functions of the healthy as well as diseased brain, including the control of regenerative responses.

In patients suffering from Alzheimer's disease, astrocytes in the vicinity of amyloid plaques and degenerating neurons become hyperactive.

Until now, many researchers considered this astrocyte hyperactivity in the brains of Alzheimer's disease patients as negative and contributing to the progression of this devastating disease.

The current study generated groundbreaking data with important implications. The US and Swedish research teams used a mouse model of Alzheimer's disease in which they genetically reduced astrocyte hyperactivity. They found that such mice developed more amyloid deposits and showed more pronounced signs of neurodegeneration than mice with normal response of astrocytes.

This suggests that astrocyte response to the disease process slows down the disease progression.

- We are truly exited about these findings. Now we need to understand the mechanism underlying the beneficial role of hyperactive astrocytes in Alzheimer's disease progression. Understanding this process on a molecular level should help us to design strategies for optimization of the astrocyte response, says Prof. Milos Pekny.

- We see that astrocyte hyperactivity in Alzheimer's disease brains is tightly connected to activation of microglia, the brain's own immune cells. This implies that the two cell types communicate to mediate a coordinated response to disease states, says Prof. Jin-Moo Lee.

This international collaborative team of neuroscientists is pursuing further studies to understand molecular mechanisms by which astrocytes prevent the deposition of amyloid plaques in Alzheimer's disease.


Story Source:

The above story is based on materials provided by Expertsvar. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. W. Kraft, X. Hu, H. Yoon, P. Yan, Q. Xiao, Y. Wang, S. C. Gil, J. Brown, U. Wilhelmsson, J. L. Restivo, J. R. Cirrito, D. M. Holtzman, J. Kim, M. Pekny, J.-M. Lee. Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. The FASEB Journal, 2012; DOI: 10.1096/fj.12-208660

Cite This Page:

Expertsvar. "Astrocytes as a novel target in Alzheimer’s disease." ScienceDaily. ScienceDaily, 10 October 2012. <www.sciencedaily.com/releases/2012/10/121010084158.htm>.
Expertsvar. (2012, October 10). Astrocytes as a novel target in Alzheimer’s disease. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2012/10/121010084158.htm
Expertsvar. "Astrocytes as a novel target in Alzheimer’s disease." ScienceDaily. www.sciencedaily.com/releases/2012/10/121010084158.htm (accessed July 26, 2014).

Share This




More Mind & Brain News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins