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New advance could help soldiers, athletes, others rebound from traumatic brain injuries

Date:
October 17, 2012
Source:
American Chemical Society
Summary:
A potential treatment for traumatic brain injury (TBI), which affects thousands of soldiers, auto accident victims, athletes and others each year, has shown promise in laboratory research, scientists are reporting. TBI can occur in individuals who experience a violent blow to the head, a gunshot injury or exposure to an explosion. TBI currently cannot be treated and may result in permanent brain damage or death.
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Advance could help victims of traumatic brain injuries such as soldiers injured in explosions, as well as athletes and accident victims.
Credit: U.S. Army

A potential new treatment for traumatic brain injury (TBI), which affects thousands of soldiers, auto accident victims, athletes and others each year, has shown promise in laboratory research, scientists are reporting. TBI can occur in individuals who experience a violent blow to the head that makes the brain collide with the inside of the skull, a gunshot injury or exposure to a nearby explosion. The report on TBI, which currently cannot be treated and may result in permanent brain damage or death, appears in the journal ACS Nano.

Thomas Kent, James Tour and colleagues explain that TBI disrupts the supply of oxygen-rich blood to the brain. With the brain so oxygen-needy -- accounting for only 2 percent of a person's weight, but claiming 20 percent of the body's oxygen supply -- even a mild injury, such as a concussion, can have serious consequences. Reduced blood flow and resuscitation result in a build-up of free-radicals, which can kill brain cells. Despite years of far-ranging efforts, no effective treatment has emerged for TBI. That's why the scientists tried a new approach, based on nanoparticles so small that 1000 would fit across the width of a human hair.

They describe development and successful laboratory tests of nanoparticles, called PEG-HCCs. In laboratory rats, the nanoparticles acted like antioxidants, rapidly restoring blood flow to the brain following resuscitation after TBI. "This finding is of major importance for improving patient health under clinically relevant conditions during resuscitative care, and it has direct implications for the current [TBI] war-fighter victims in the Afghanistan and Middle East theaters," they say.


Story Source:

The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brittany R. Bitner, Daniela C. Marcano, Jacob M. Berlin, Roderic H. Fabian, Leela Cherian, James C. Culver, Mary E. Dickinson, Claudia S. Robertson, Robia G. Pautler, Thomas A. Kent, James M. Tour. Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury. ACS Nano, 2012; 6 (9): 8007 DOI: 10.1021/nn302615f

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American Chemical Society. "New advance could help soldiers, athletes, others rebound from traumatic brain injuries." ScienceDaily. ScienceDaily, 17 October 2012. <www.sciencedaily.com/releases/2012/10/121017132029.htm>.
American Chemical Society. (2012, October 17). New advance could help soldiers, athletes, others rebound from traumatic brain injuries. ScienceDaily. Retrieved August 2, 2015 from www.sciencedaily.com/releases/2012/10/121017132029.htm
American Chemical Society. "New advance could help soldiers, athletes, others rebound from traumatic brain injuries." ScienceDaily. www.sciencedaily.com/releases/2012/10/121017132029.htm (accessed August 2, 2015).

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