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New antidote for smoke-related cyanide toxicity shows promise

Date:
October 22, 2012
Source:
American College of Chest Physicians
Summary:
Smoke inhalation is the major cause of death in fire victims due to cyanide poisoning. However, new research shows that a new antidote, cobinamide, may help reverse the effects of cyanide toxicity.
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Smoke inhalation is the major cause of death in fire victims due to cyanide poisoning. However, new research presented at CHEST 2012, the annual meeting of the American College of Chest Physicians, shows that a new antidote, cobinamide, may help reverse the effects of cyanide toxicity.

Researchers from multiple institutions, including the University of California Irvine Medical Center, exposed six ventilator-supported New Zealand white rabbits to cold smoke breaths until toxic carbon monoxide levels were achieved, concurrent with intravenous cyanide infusion. Intravenous cobinamide was administered in treatment arm animals and compared with control responses.

Results showed that intravenous cobinamide reversed cyanide toxicity in these animals in the face of smoke-induced carbon monoxide exposure, without evident adverse effects. Researchers concluded that cobinamide shows promise as a potential antidote for cyanide poisoning in smoke inhalation victims and that it could potentially be administered in mass casualty exposure scenarios.

This study was presented during CHEST 2012, the annual meeting of the American College of Chest Physicians, held October 20 -- 25, in Atlanta, Georgia.


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The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


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American College of Chest Physicians. "New antidote for smoke-related cyanide toxicity shows promise." ScienceDaily. ScienceDaily, 22 October 2012. <www.sciencedaily.com/releases/2012/10/121022081012.htm>.
American College of Chest Physicians. (2012, October 22). New antidote for smoke-related cyanide toxicity shows promise. ScienceDaily. Retrieved May 24, 2015 from www.sciencedaily.com/releases/2012/10/121022081012.htm
American College of Chest Physicians. "New antidote for smoke-related cyanide toxicity shows promise." ScienceDaily. www.sciencedaily.com/releases/2012/10/121022081012.htm (accessed May 24, 2015).

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