Featured Research

from universities, journals, and other organizations

Blood chromosome differences are linked to pancreatic cancer

Date:
October 23, 2012
Source:
University of Wisconsin-Madison
Summary:
A new study shows that a blood marker is linked to pancreatic cancer. Researchers say the new study is the first time pancreatic cancer risk has been linked to differences in telomeres' length in blood cells.

A new study shows that a blood marker is linked to pancreatic cancer, according to a study published October 23 by scientists at the University of Wisconsin Carbone Cancer Center and Mayo Clinic.

First author Dr. Halcyon Skinner, assistant professor of population health sciences at the University of Wisconsin School of Medicine and Public Health, says the study is the first time pancreatic cancer risk has been linked to differences in telomeres' length in blood cells.

"This suggests a new avenue to identify those with pancreatic cancer or those at risk of developing the cancer in the future,'' he says.

Skinner's colleagues at Mayo Clinic took blood samples from more than 1,500 people -- 499 of them with a diagnosis of pancreatic cancer and 963 of them cancer-free control subjects. Specifically, the scientists were interested in the length of the telomeres -- the end caps on chromosomes -- found in white blood cells. They found a direct relationship with the risk of pancreatic cancer: the shorter the telomeres, the more likely a person was to have pancreatic cancer.

Telomeres maintain the stability of genes, and are known to shorten with age as cells divide. People of the same chronological age can have vastly different telomere lengths. In other words, some people's cells can by viewed as biologically older than cells from other people the same age.

"We know that people with many factors that are classically unhealthy also tend to have shorter telomeres. Those who have had stressful lives, exposed to chronic inflammation, have poor glucose control or smoked cigarettes tend to have shorter telomeres, and that can set the stage for genetic damage,'' Skinner explains.

Shortened telomeres in the blood have already been associated with other types of cancer, including colon cancer.

"We found the same relationship with pancreatic cancer, and for the vast majority of our participants, there was a direct linear relationship," he says, "the shorter the telomere, the higher the likelihood of pancreatic cancer."

But because shorter telomere length is also associated with the development of other cancers and other diseases of aging, measurement of telomere length alone is not a specific marker for pancreatic cancer.

Dr. Lisa A. Boardman, of Mayo Clinic, who led the overall study, says that future studies need to address if telomere length and other markers of pancreatic cancer should be combined to create a test that could be used clinically.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Journal Reference:

  1. Halcyon G. Skinner, Ronald E. Gangnon, Kristin Litzelman, Ruth A. Johnson, Suresh T. Chari, Gloria M. Petersen, and Lisa A. Boardman. Telomere Length and Pancreatic Cancer: A Case–Control Study. Cancer Epidemiol Biomarkers Prev, October 23, 2012 DOI: 10.1158/1055-9965.EPI-12-0671

Cite This Page:

University of Wisconsin-Madison. "Blood chromosome differences are linked to pancreatic cancer." ScienceDaily. ScienceDaily, 23 October 2012. <www.sciencedaily.com/releases/2012/10/121023134820.htm>.
University of Wisconsin-Madison. (2012, October 23). Blood chromosome differences are linked to pancreatic cancer. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/10/121023134820.htm
University of Wisconsin-Madison. "Blood chromosome differences are linked to pancreatic cancer." ScienceDaily. www.sciencedaily.com/releases/2012/10/121023134820.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins