Featured Research

from universities, journals, and other organizations

Research findings breathe new life into lung disease

Date:
October 24, 2012
Source:
St. Michael's Hospital
Summary:
New research shows that while muscle cells are responsible for constricting or dilating the blood vessels, they are not responsible for sensing the amount of oxygen that gets to the lungs.

It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood vessels, they are not responsible for sensing the amount of oxygen that gets to the lungs. That message comes from the endothelial cells -- special cells that line the blood vessels -- along a "signalling pathway."

Related Articles


When a person is low on oxygen, blood vessels throughout the body expand to improve the delivery of this vital molecule to the tissues. The one exception is that when oxygen is low in the lungs, blood vessels there constrict. When this condition persists, it causes pulmonary hypertension -- a lung disorder where the arteries that carry blood from the heart to the lungs become smaller -- and makes it difficult for the heart to pump blood through the lungs. This leads to enlargement of the right heart, called right heart failure.

Dr. Wolfgang Kuebler, a Li Ka Shing Knowledge Institute scientist at St. Michael's Hospital, has found that the endothelial cells play a much larger role in the constriction of blood vessels in response to the lack of oxygen and in subsequent pulmonary hypertension, than previously believed. The findings of his study, which was conducted on mice, have been published online in the Journal of Clinical Investigation.

"The vascular endothelial cells have always been regarded as a bystander, but we've discovered that lung disease in response to low oxygen originates at this level, that the message is sent by these cells," said Dr. Kuebler. He said that if there were a way to block, or inhibit, this communication along the signalling pathway between the endothelial cells and the smooth muscle cells, we could potentially prevent right heart failure, a fairly common disease among patients with lung disease.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. The original article was written by Evelyne Jhung. Note: Materials may be edited for content and length.


Journal Reference:

  1. Liming Wang, Jun Yin, Hannah T. Nickles, Hannes Ranke, Arata Tabuchi, Julia Hoffmann, Christoph Tabeling, Eduardo Barbosa-Sicard, Marc Chanson, Brenda R. Kwak, Hee-Sup Shin, Songwei Wu, Brant E. Isakson, Martin Witzenrath, Cor de Wit, Ingrid Fleming, Hermann Kuppe, Wolfgang M. Kuebler. Hypoxic pulmonary vasoconstriction requires connexin 40–mediated endothelial signal conduction. Journal of Clinical Investigation, 2012; DOI: 10.1172/JCI59176

Cite This Page:

St. Michael's Hospital. "Research findings breathe new life into lung disease." ScienceDaily. ScienceDaily, 24 October 2012. <www.sciencedaily.com/releases/2012/10/121024141626.htm>.
St. Michael's Hospital. (2012, October 24). Research findings breathe new life into lung disease. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2012/10/121024141626.htm
St. Michael's Hospital. "Research findings breathe new life into lung disease." ScienceDaily. www.sciencedaily.com/releases/2012/10/121024141626.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins