Featured Research

from universities, journals, and other organizations

Sleep apnea can reduce severity of cardiac injury during a heart attack

Date:
October 25, 2012
Source:
Montefiore Medical Center
Summary:
Patients with sleep apnea have less severe cardiac injury during an acute non-fatal Myocardial Infarction (MI) compared to patients without sleep apnea, according to a new study.

Patients with sleep apnea have less severe cardiac injury during an acute non-fatal Myocardial Infarction (MI) compared to patients without sleep apnea, according to a Montefiore Medical Center study, entitled "Obstructive Sleep Apnea and Acute Myocardial Infarction Severity: Ischemic Preconditioning," to be published in Sleep and Breathing on Oct. 24.

"Our results appear to be contrary to existing literature that identifies obstructive sleep apnea (OSA) to be a risk factor for Myocardial Infarction," said Neomi Shah, MD, MPH, Pulmonary Sleep Lab, Associate Director, Montefiore Medical Center, and Assistant Professor of Medicine, Albert Einstein College of Medicine of Yeshiva University, and principal investigator of the study. "While our data do not refute a widely accepted view that sleep apnea is a risk factor for the development of a coronary artery disease related event such as a Myocardial Infarction, our study suggests that obstructive sleep apnea can provide a degree of cardioprotection during the acute phase of a Myocardial Infarction."

The study that screened over 6,000 hospitalized patients on the cardiology units at Montefiore found that this degree of cardioproetection can reduce the severity of the heart attack. A number of factors led to this conclusion. First, acute MI patients with severe sleep apnea tended to have a lower median level of peak Troponin-T compared to those without OSA. Troponin-T is a marker in the blood for myocardial cell death and it accurately predicts the severity of a heart attack. In addition, patients with OSA had lower levels of creatine phosphokinase (CPK) as compared with non-OSA patients. CPK is an enzyme found in the blood and when it is high, it usually indicates that there has been an injury or stress to muscle mass. These novel findings suggest that OSA may be cardioprotective in the acute phase of a MI.

The final number of patients in the analytical sample of this study was 136, based on the number who agreed to participate and who had adequate sleep data. Of this group, 35% had obstructive sleep apnea. Their median age was 58 years and 47% were men. These patients also exhibited a high prevalence of hypertension (77%), hyperlipidemia (56%) and diabetes (50%). Patients with OSA were significantly older than those without OSA (age 62 vs. 52).

The study was conducted from April, 2010 to May, 2011.

Dr. Shah, who has been Associate Director of the Pulmonary Sleep Lab at Montefiore Medical Center since 2008, has focused her research interests on understanding the relationship between OSA and coronary artery disease. She received her medical degree from Robert Wood Johnson Medical School and completed her residency in internal medicine at the University of Medicine & Dentistry in Newark, NJ. She completed her fellowship in pulmonary, critical care and sleep medicine at Yale University School of Medicine.

In addition to Dr. Shah, the research team included Susan Redline, MD, MPH, H. Klar Yaggi, MD, MPH, Richard Wu, MD, C. George Zhao, MD, Robert Ostfeld, MD, Mark Menegus, MD, Daniel Tracy, Elizabeth Brush, BA, W. David Appel, MD, and Robert Kaplan, PhD.


Story Source:

The above story is based on materials provided by Montefiore Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neomi Shah, Susan Redline, H. Klar Yaggi, Richard Wu, C. George Zhao, Robert Ostfeld, Mark Menegus, Daniel Tracy, Elizabeth Brush, W. David Appel, Robert C. Kaplan. Obstructive sleep apnea and acute myocardial infarction severity: ischemic preconditioning? Sleep and Breathing, 2012; DOI: 10.1007/s11325-012-0770-7

Cite This Page:

Montefiore Medical Center. "Sleep apnea can reduce severity of cardiac injury during a heart attack." ScienceDaily. ScienceDaily, 25 October 2012. <www.sciencedaily.com/releases/2012/10/121025095020.htm>.
Montefiore Medical Center. (2012, October 25). Sleep apnea can reduce severity of cardiac injury during a heart attack. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2012/10/121025095020.htm
Montefiore Medical Center. "Sleep apnea can reduce severity of cardiac injury during a heart attack." ScienceDaily. www.sciencedaily.com/releases/2012/10/121025095020.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins