Featured Research

from universities, journals, and other organizations

Overweight, obesity in adolescents linked with increased risk for end-stage renal disease over time

Date:
October 29, 2012
Source:
JAMA and Archives Journals
Summary:
Being overweight and obese during adolescence appears related to an increased risk of all-cause treated end-stage renal disease during a 25-year period.

Being overweight and obese during adolescence appears related to an increased risk of all-cause treated end-stage renal disease (ESRD) during a 25-year period, according to a report published Online First by Archives of Internal Medicine, a JAMA Network publication.

Children and adolescents with high body mass index (BMI) often become obese adults, and obese adults are at risk for chronic conditions such as diabetes, which can mean future risk of chronic kidney disease and ESRD, according to the study background.

Asaf Vivante, M.D., of the Israeli Defense Forces Medical Corps and the Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel, and colleagues examined the association between BMI in adolescence and the risk for all-cause, diabetic and nondiabetic ESRD.

Medical data for almost 1.2 million adolescents (17 years old) who were examined for fitness for Israeli military service between January 1967 and December 1997 were linked to the Israeli ESRD registry in a nationwide population-based retrospective study.

"In this long-term nationwide population-based study, overweight and obesity at age 17 years were strongly and positively associated with the incidence of future treated ESRD, although the absolute risk for ESRD remains low," the authors comment.

The study results indicate that 874 participants (713 men, 161 women) developed treated ESRD for an overall incidence rate of 2.87 cases per 100,000 person-years during more than 30 million follow-up person-years. Compared to normal-weight adolescents, those adolescents who were overweight and obese had an increased future risk for treated ESRD, with incidence rates of 6.08 and 13.40 cases per 100,000 person-years, respectively, the results show.

Researchers also estimated the association between BMI and treated diabetic ESRD and suggest that compared with normal weight adolescents, overweight adolescents at 17 years old had six times the risk for diabetic ESRD and obese adolescents at 17 years old had 19 times the risk for diabetic ESRD, according to the results.

"Although the results for diabetic ESRD were remarkable, with risks increasing six-fold and 19-fold among overweight and obese adolescents, respectively, our results also indicate a substantial association between elevated BMI and nondiabetic ESRD," the authors note.

Commentary: The Skinny on Obesity, End-Stage Renal Disease

In an invited commentary, Kirsten L. Johansen, M.D., of the San Francisco Veterans Affairs Medical Center, writes: "A study by Vivante et al in this issue of the Archives adds the development of end-stage renal disease (ESRD) to the list of adverse outcomes associated with adolescent overweight and obesity."

"The association of obesity with ESRD is good news and bad news. The good news is that obesity represents a potentially modifiable risk factor, and control of weight and the hypertension and inactivity that often accompany excess adiposity could prevent or slow the development of some cases of ESRD and may potentially reduce the morbidity and mortality associated with CKD [chronic kidney disease]. The bad news is that it is not easy to address obesity," Johansen continues.

"Although there is no evidence that it is ever too late to improve outcomes by increasing physical activity or shedding excess weight, the results reported by Vivante et al in this issue of the Archives highlight the potential advantages of starting early before chronic disease has developed and unhealthy lifestyles have become lifelong habits," Johansen concludes.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Asaf Vivante, Eliezer Golan, Dorit Tzur, Adi Leiba, Amir Tirosh, Karl Skorecki,Ronit Calderon-Margalit. Body Mass Index in 1.2 Million Adolescents and Risk for End-Stage Renal Disease. Arch Intern Med, 2012;():1-7 DOI: 10.1001/2013.jamainternmed.85

Cite This Page:

JAMA and Archives Journals. "Overweight, obesity in adolescents linked with increased risk for end-stage renal disease over time." ScienceDaily. ScienceDaily, 29 October 2012. <www.sciencedaily.com/releases/2012/10/121029170938.htm>.
JAMA and Archives Journals. (2012, October 29). Overweight, obesity in adolescents linked with increased risk for end-stage renal disease over time. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/10/121029170938.htm
JAMA and Archives Journals. "Overweight, obesity in adolescents linked with increased risk for end-stage renal disease over time." ScienceDaily. www.sciencedaily.com/releases/2012/10/121029170938.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins