Featured Research

from universities, journals, and other organizations

Smoking causes asthma in second generation offspring, study shows

Date:
October 30, 2012
Source:
BioMed Central Limited
Summary:
The dangers of smoking on smokers and their children are widely known but new research demonstrates that nicotine exposure also causes asthma in the smoker’s grandchildren. Asthma is a major public health problem. It is the most common chronic disease of childhood. While there are many factors which contribute to asthma maternal smoking during pregnancy is a well known, and avoidable, risk.

The dangers of smoking on smokers and their children are widely known but new research published in BioMed Central's open access journal BMC Medicine demonstrates that nicotine exposure also causes asthma in the smoker's grandchildren.

Asthma is a major public health problem. It is the most common chronic disease of childhood. While there are many factors which contribute to asthma maternal smoking during pregnancy is a well known, and avoidable, risk.

During pregnancy nicotine can affect a developing fetus' lungs, predisposing the infant to childhood asthma. Researchers from Harbor-UCLA Medical Centre, California, tested the effect of nicotine exposure during pregnancy on rats, looking not only at their pups (F1) but also at second generation pups (F2).

Exposure inside the uterus resulted in both male and female (F1) offspring having reduced lung function consistent with asthma. It also impaired lung function of their own offspring (F2), even though the F1 rats were not themselves exposed to nicotine once they were born. Levels of proteins increased by maternal smoking in the lungs of their offspring such as fibronectin, collagen and nicotinic aceylcholine receptors, were also found to be raised in the grandchildren. Similarly the expression of PPARγ, a normal lung development, was reduced in first and second generation offspring.

Dr Virender Rehan, who led this study commented, "When we looked at the effect of nicotine on DNA in the testes or ovaries of the rats they found that nicotine increased the level of methylation in the testes but reduced it in the ovaries. Nicotine also altered methylation of histones in a sex-dependent manner. These epigenetic marks may be the mechanism behind how nicotine-induced asthma is transmitted from one generation to the next."

Treating the mothers with a synthetic version of PPARγ, known to normalise lung function in nictotine exposed offspring also prevented lung damage to F2 offspring and restored normal histone modification patterns in their lungs.

The effects of smoking during pregnancy are, it seems, very long lasting. Stop smoking education and intervention aimed at mothers-to-be and women planning pregnancy needs to take into account the fact that nicotine itself contains dangers to their children and their children's children.


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Virender K Rehan, Jie Liu, Erum Naeem, Jia Tian, Reiko Sakurai, Kenny Kwong, Omid Akbari and John S Torday. Perinatal nicotine exposure induces asthma in second generation offspring. BMC Medicine, 2012 DOI: 10.1186/1741-7015-10-129

Cite This Page:

BioMed Central Limited. "Smoking causes asthma in second generation offspring, study shows." ScienceDaily. ScienceDaily, 30 October 2012. <www.sciencedaily.com/releases/2012/10/121030062204.htm>.
BioMed Central Limited. (2012, October 30). Smoking causes asthma in second generation offspring, study shows. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2012/10/121030062204.htm
BioMed Central Limited. "Smoking causes asthma in second generation offspring, study shows." ScienceDaily. www.sciencedaily.com/releases/2012/10/121030062204.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins