Featured Research

from universities, journals, and other organizations

Common food preservative may slow, even stop tumor growth

Date:
October 30, 2012
Source:
University of Michigan
Summary:
Nisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a new study found.

Top control group shows growth of tumors that weren't treated with nisin. Bottom group shows growth of tumors that were treated with nisin. Those tumors are significantly smaller.
Credit: Image courtesy of University of Michigan

Nisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a University of Michigan study found.

What makes this particularly good news is that the Food and Drug Administration and the World Health Organization approved nisin as safe for human consumption decades ago, says Yvonne Kapila, the study's principal investigator and professor at the University of Michigan School of Dentistry.

This means that obtaining FDA approval to test nisin's suggested cancer-fighting properties on patients in a clinical setting won't take as long as a new therapy that hasn't been tried yet on people, she says.

Antibacterial agents like nisin alter cell properties in bacteria to render it harmless. However, it's only recently that scientists began looking to antibacterial agents like nisin to see if they altered properties in other types of cells, such as cancer cells or cells in tumors.

Oral cancer is a leading cause of death worldwide, and oral squamous cell carcinoma accounts for more than 90 percent of oral cancers. However, survival rates for oral cancer haven't improved in decades, according to the study.

"The poor five-year survival rates for oral cancer underscore the need to find new therapies for oral cancer," Kapila said. "The use of small antibacterial agents, like nisin, to treat cancer is a new approach that holds great promise. Nisin is a perfect example of this potential because it has been used safely in humans for many years, and now the laboratory studies support its anti-tumor potential."

The U-M study, which looked at the use of antimicrobials to fight cancerous tumors, suggests nisin, in part, slows cell proliferation or causes cell death through the activation of a protein called CHAC1 in cancer cells, a protein known to influence cell death.

The study is the first to show CHAC1's new role in promoting cancer cell death under nisin treatment. The findings also suggest that nisin may work by creating pores in the cancer cell membranes that allow an influx of calcium. It's unclear what role calcium plays in nisin-triggered cell death, but it's well known that calcium is a key regulator in cell death and survival.

Additionally, the findings suggest that nisin slows or stops tumor growth by interrupting the cell cycle in "bad" cells but not the good cells; thus nisin stops cancer cell proliferation but doesn't hurt good cells.


Story Source:

The above story is based on materials provided by University of Michigan. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nam E. Joo, Kathryn Ritchie, Pachiyappan Kamarajan, Di Miao, Yvonne L. Kapila. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. Cancer Medicine, 2012; DOI: 10.1002/cam4.35

Cite This Page:

University of Michigan. "Common food preservative may slow, even stop tumor growth." ScienceDaily. ScienceDaily, 30 October 2012. <www.sciencedaily.com/releases/2012/10/121030161232.htm>.
University of Michigan. (2012, October 30). Common food preservative may slow, even stop tumor growth. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2012/10/121030161232.htm
University of Michigan. "Common food preservative may slow, even stop tumor growth." ScienceDaily. www.sciencedaily.com/releases/2012/10/121030161232.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins