Featured Research

from universities, journals, and other organizations

Discovering how stomach cancer spreads

Date:
November 13, 2012
Source:
University of Liverpool
Summary:
Scientists have found that the production of a protein that prevents the growth and spread of cancerous cells is impaired in patients with gastric cancer.

A cancer cell. Cancer of the stomach is the second most common cause of death due to malignant disease worldwide.
Credit: Image courtesy of University of Liverpool

Scientists at the University of Liverpool have found that the production of a protein that prevents the growth and spread of cancerous cells is impaired in patients with gastric cancer.

Related Articles


Cancer of the stomach is the second most common cause of death due to malignant disease worldwide. New research findings at Liverpool, however, could contribute to the development of future gastric cancer therapies by restoring the functions of a protein called, TGFβig-h3.

Development of future therapies

The protein is released by cells called myofibroblasts, which form part of the supporting tissue around cancer cells. The environment of myofibroblasts, blood vessels and other cell types, allows cancer to survive and can become as high as 70-90% of the total tumour mass.

Myofibroblasts are highly mobile cells that produce and release multiple substances that change cancer behaviour by altering their environment, leading to the growth and spread of cancerous cells. Scientists at Liverpool have now discovered that in tumours of advanced gastric cancer patients, the myofibroblasts decrease the release of a protein that would normally inhibit the growth and spread of the disease.

Long-term recovery

Professor Andrea Varro, from the University's Institute of Translational Medicine, explains "This protein normally acts as an anchor to link cells to proteins in the cancer cell environment restricting cancerous cells to the vicinity in which they have grown. This allows targeting of treatments to the area, but in advanced stages of the disease the effects of this protein are diminished, increasing the risk of the disease spreading to other parts of the body.

"We hope that this work will help develop future treatments that are based on restoring the functions of this protein, contributing to the long-term recovery of patients with this often fatal disease."


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Holmberg, M. Quante, I. Steele, J. D. Kumar, S. Balabanova, C. Duval, M. Czepan, Z. Rakonczay, L. Tiszlavicz, I. Nemeth, G. Lazar, Z. Simonka, R. Jenkins, P. Hegyi, T. C. Wang, G. J. Dockray, A. Varro. Release of TGFig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression. Carcinogenesis, 2012; 33 (8): 1553 DOI: 10.1093/carcin/bgs180

Cite This Page:

University of Liverpool. "Discovering how stomach cancer spreads." ScienceDaily. ScienceDaily, 13 November 2012. <www.sciencedaily.com/releases/2012/11/121113122649.htm>.
University of Liverpool. (2012, November 13). Discovering how stomach cancer spreads. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2012/11/121113122649.htm
University of Liverpool. "Discovering how stomach cancer spreads." ScienceDaily. www.sciencedaily.com/releases/2012/11/121113122649.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com
India's Bidi Workers Suffer for 1,000-a-Day Habit

India's Bidi Workers Suffer for 1,000-a-Day Habit

AFP (Apr. 19, 2015) Popular because of their cheap price, bidis are the main source of income for millions of women and children who manufacture these Indian traditional cigarettes for roughly a dollar a day in dire conditions. Duration: 02:26 Video provided by AFP
Powered by NewsLook.com
Elmo Teams Up With Surgeon General To Promote Vaccinations

Elmo Teams Up With Surgeon General To Promote Vaccinations

Newsy (Apr. 18, 2015) Surgeon General Vivek Murthy released a video with Elmo to promote vaccinations. The video was released the same day the measles outbreak ended. Video provided by Newsy
Powered by NewsLook.com
Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins