Featured Research

from universities, journals, and other organizations

Genetics point to serious pregnancy complication, pre-eclampsia

Date:
November 15, 2012
Source:
University of Adelaide
Summary:
New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.

New research at the University of Adelaide has revealed a genetic link in pregnant mums -- and their male partners -- to pre-eclampsia, a life-threatening complication during pregnancy.

Related Articles


Pre-eclampsia involves high blood pressure and fluid retention and can cause damage to the kidneys and liver. About 7% of pregnancies are affected by pre-eclampsia.

In a paper now online in the journal Placenta ahead of print publication, the researchers say they have found a genetic variant involving the AGT2R gene, which may predispose women to pre-eclampsia.

However, the genetic variant is only associated with pre-eclampsia when the pregnant mother is overweight or obese.

"Being able to predict which women are at risk of pre-eclampsia is a very important goal in obstetrics," says Professor Claire Roberts from the University of Adelaide's Robinson Institute.

Professor Roberts, Dr Ang Zhou and Professor Gus Dekker from the Robinson Institute studied data from the SCOPE study, involving more than 2000 women and their partners in Adelaide, Australia and Auckland, New Zealand.

Women who developed pre-eclampsia who were also overweight or obese were twice as likely to carry the AGT2R gene variant than the common form of the gene. The male partners of women with pre-eclampsia were also twice as likely to carry the variant gene. Their babies were three times more likely to carry the variant.

"This is a condition that can run in families," Professor Roberts says. "With both the mother and the father passing on their variant genes to their children, this places the child at greater risk of parenting a pre-eclamptic pregnancy."

Professor Roberts says the genetic variant is linked with restricted blood flow to the placenta.

"Impaired blood flow in the uterine artery is characterized by a 'notching effect' that appears on a Doppler ultrasound at 20 weeks gestation. Uterine artery notching has previously been associated with pre-eclampsia, and this restricted blood flow is due to impaired placental development," Professor Roberts says.

The researchers say the genetic variant has only a subtle effect in women of normal weight, but in overweight and obese women it appears to independently contribute to the risk of pre-eclampsia.

"Understanding this association could help to predict which women are likely to develop pre-eclampsia," Professor Roberts says.

"However, it also helps to reinforce the message that a normal weight prior to pregnancy will lower the risk of serious complications -- being overweight or obese increases the risk of complications."


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Zhou, G.A. Dekker, E.R. Lumbers, S.Y. Lee, S.D. Thompson, L.M.E. McCowan, C.T. Roberts. The association of AGT2R polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI. Placenta, 2012; DOI: 10.1016/j.placenta.2012.10.007

Cite This Page:

University of Adelaide. "Genetics point to serious pregnancy complication, pre-eclampsia." ScienceDaily. ScienceDaily, 15 November 2012. <www.sciencedaily.com/releases/2012/11/121115132613.htm>.
University of Adelaide. (2012, November 15). Genetics point to serious pregnancy complication, pre-eclampsia. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2012/11/121115132613.htm
University of Adelaide. "Genetics point to serious pregnancy complication, pre-eclampsia." ScienceDaily. www.sciencedaily.com/releases/2012/11/121115132613.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins