Featured Research

from universities, journals, and other organizations

Delayed treatment for advanced breast cancer has 'profound effect'

Date:
November 29, 2012
Source:
Ohio State University Medical Center
Summary:
Results from a recent study show women who wait more than 60 days to begin treatment for advanced breast cancer face significantly higher risks of dying than women who start therapy shortly after diagnosis.

Results from a new study conducted by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) show women who wait more than 60 days to begin treatment for advanced breast cancer face significantly higher risks of dying than women who start therapy shortly after diagnosis.

Related Articles


"We wanted to see whether delaying treatment affected mortality rates among women with breast cancer," says Electra D. Paskett, associate director for population sciences at OSUCCC-James. "It's been shown that early detection and appropriate, timely treatment can increase five year survival rates to as high as 98 percent. Until this study, we didn't know the profound effect delaying treatment could have," she said.

Paskett is the senior author on the study, which is published online by the Journal of Clinical Oncology. In the study, researchers retrospectively examined 1,786 women enrolled in North Carolina Medicaid system who were diagnosed with breast cancer from January 1, 2000 through December 31, 2002, using the linked North Carolina Cancer Registry-Medicaid Claims database. Follow-up data were available through July 31, 2006.

The median time from biopsy-confirmed diagnosis to the initiation of treatment was 22 days. Sixty-six percent of the women started treatment within 30 days, and nearly all (90 percent) started treatment within 60 days. There was no difference in survival rates for those treated by 60 days.

However, for one in ten women studied, treatment started more than 60 days after their cancer diagnosis. Among those who had advanced cases of breast cancer, a delay of more than 60 days was associated with an 85 percent higher risk of breast cancer-related death, and a 66 percent higher risk of death overall, compared with women who were treated sooner.

"We're finding as we do research, it is really the lower income population that suffers the highest burden of all diseases," says Paskett. "This study suggests that ten percent of women can't get access to care, or it takes a longer time to get access to care."

Paskett says interventions to remove barriers and improve the timeliness of breast cancer treatment should focus on late-stage patients. Paskett recently published a study that confirmed patient navigators, often part of the clinical team, help patients negotiate the various complexities of the health care system and play a valuable role in helping breast cancer patients start treatment earlier.

"This research shows we have an opportunity to improve breast cancer outcomes by helping women who are diagnosed at late-stage to get started with treatment sooner," says Paskett. "Even if the goal of treatment isn't curative, early treatment seems to prolong survival."

The study was funded by grant 1R01CA121317 from the National Cancer Institute.


Story Source:

The above story is based on materials provided by Ohio State University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. M. McLaughlin, R. T. Anderson, A. K. Ferketich, E. E. Seiber, R. Balkrishnan, E. D. Paskett. Effect on Survival of Longer Intervals Between Confirmed Diagnosis and Treatment Initiation Among Low-Income Women With Breast Cancer. Journal of Clinical Oncology, 2012; DOI: 10.1200/JCO.2012.39.7695

Cite This Page:

Ohio State University Medical Center. "Delayed treatment for advanced breast cancer has 'profound effect'." ScienceDaily. ScienceDaily, 29 November 2012. <www.sciencedaily.com/releases/2012/11/121129143535.htm>.
Ohio State University Medical Center. (2012, November 29). Delayed treatment for advanced breast cancer has 'profound effect'. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2012/11/121129143535.htm
Ohio State University Medical Center. "Delayed treatment for advanced breast cancer has 'profound effect'." ScienceDaily. www.sciencedaily.com/releases/2012/11/121129143535.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins